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<p>The INDIGO trial demonstrated improved progression-free survival under vorasidenib in IDH-mutated grade 2 glioma patients. However, the pattern of vorasidenib effects remains unknown. We thus performed a retrospective analysis of tumor kinetics in eight patients enrolled in the INDIGO trial. Tumor diameters (computed from FLAIR volumetry) and their slopes were individually estimated, before and under vorasidenib. Three patients showed no change in slope. Three patients exhibited a marked slope decrease, and two demonstrated slope inversion. Tumor diameter slopes allows individual assessment of radiological response, providing clinically relevant insights that cannot be captured by the cohort-level analysis performed in the INDIGO trial.</p>

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Assessing radiological response of IDH-mutated glioma to vorasidenib by tumor diameter slopes: a series of 8 cases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Emmanuel Mandonnet

摘要

The INDIGO trial demonstrated improved progression-free survival under vorasidenib in IDH-mutated grade 2 glioma patients. However, the pattern of vorasidenib effects remains unknown. We thus performed a retrospective analysis of tumor kinetics in eight patients enrolled in the INDIGO trial. Tumor diameters (computed from FLAIR volumetry) and their slopes were individually estimated, before and under vorasidenib. Three patients showed no change in slope. Three patients exhibited a marked slope decrease, and two demonstrated slope inversion. Tumor diameter slopes allows individual assessment of radiological response, providing clinically relevant insights that cannot be captured by the cohort-level analysis performed in the INDIGO trial.