Scholarlink

Purpose <p>The Ki-67 proliferation index (Ki-67 PI) has been associated with meningioma recurrence, yet its clinical utility remains debated. Whether Ki-67 PI provides prognostic information across subgroups defined by both WHO grade and extent of resection remains to be investigated.</p> Methods <p>We analyzed 5,050 patients with intracranial meningiomas from the international <i>PERNS</i> cohort (42 centers, diagnosed between 1989–2019) who underwent surgical resection without postoperative radiotherapy. Ki-67 PI prognostic accuracy was assessed up to 10&#xa0;years postoperatively by using ROC analyses and estimating its association with the risk of recurrence.</p> Results <p>Results demonstrated that the prognostic value of Ki-67 PI differed by subgroups defined by WHO grade and Simpson grade. For patients with the same Simpson grade (1–3), the predictive accuracy of Ki-67 PI for 10-year recurrence risk was stronger in WHO-2 than in WHO-1. Within WHO-1 and WHO-2 meningiomas, the predictive accuracy of Ki-67 PI increased with higher Simpson grade (1–3). However, no predictive value was observed in Simpson grade 4 resections regardless of WHO grade.</p> Conclusion <p>These findings highlight that Ki-67 PI should be interpreted in the context of both WHO grade and extent of resection, and, if done so, may offer potential value to refine individualized surveillance strategies in meningioma patients with gross total resection in the initial 10-year postoperative timeframe. Findings cannot be extrapolated beyond 10&#xa0;years, which may be particularly relevant for WHO-1 tumors with low Ki-67 PI and Simpson grade 1 resection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Ki-67 proliferation index and recurrence risk of intracranial meningioma: a multicenter, retrospective cohort study of 5,050 patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月6日

查看全文
  • Christian Mirian,
  • Lasse Rehné Jensen,
  • Tareq A. Juratli,
  • Andrea Daniela Maier,
  • Anders Broechner,
  • Sverre H. Torp,
  • Helen A. Shih,
  • Ramin A. Morshed,
  • Jacob S. Young,
  • Stephen T. Magill,
  • Luca Bertero,
  • Walter Stummer,
  • Dorothee Cäcilia Spille,
  • Benjamin Brokinkel,
  • Soichi Oya,
  • Satoru Miyawaki,
  • Nobuhito Saito,
  • Martin Proescholdt,
  • Yasuhiro Kuroi,
  • Konstantinos Gousias,
  • Matthias Simon,
  • Jennifer Moliterno,
  • Ricardo Prat-Acin,
  • Stéphane Goutagny,
  • Vikram C. Prabhu,
  • John T. Tsiang,
  • Johannes Wach,
  • Erdem Güresir,
  • Junkoh Yamamoto,
  • Young Zoon Kim,
  • Joo Ho Lee,
  • Daniel W. Kim,
  • Matthew Koshy,
  • Karthikeyan Perumal,
  • Mustafa K. Baskaya,
  • Donald M. Cannon,
  • Dennis C. Shrieve,
  • Chang-Ok Suh,
  • Jong Hee Chang,
  • Maria Kamenova,
  • Sven Straumann,
  • Jehuda Soleman,
  • Ilker Y. Eyüpoglu,
  • Tony Catalan,
  • Austin Lui,
  • Philip V. Theodosopoulos,
  • Michael W. McDermott,
  • Fang Wang,
  • Pedro Góes,
  • Aria Jamshidi,
  • Ricardo Komotar,
  • Michael Ivan,
  • Evan Luther,
  • Luis Souhami,
  • Marie-Christine Guiot,
  • Tamás Csonka,
  • Toshiki Endo,
  • Olivia Claire Barrett,
  • Randy Jensen,
  • Tejpal Gupta,
  • Akash J. Patel,
  • Tiemo J. Klisch,
  • Jun Won Kim,
  • Francesco Maiuri,
  • Valeria Barresi,
  • María Dolores Tabernero,
  • Simon Skyrman,
  • Ian Law,
  • David Scheie,
  • Bjarne Winther Kristensen,
  • Tina Nørgaard Munch,
  • Torstein Meling,
  • Kåre Fugleholm,
  • Paul Blanche,
  • Tiit Mathiesen

摘要

Purpose

The Ki-67 proliferation index (Ki-67 PI) has been associated with meningioma recurrence, yet its clinical utility remains debated. Whether Ki-67 PI provides prognostic information across subgroups defined by both WHO grade and extent of resection remains to be investigated.

Methods

We analyzed 5,050 patients with intracranial meningiomas from the international PERNS cohort (42 centers, diagnosed between 1989–2019) who underwent surgical resection without postoperative radiotherapy. Ki-67 PI prognostic accuracy was assessed up to 10 years postoperatively by using ROC analyses and estimating its association with the risk of recurrence.

Results

Results demonstrated that the prognostic value of Ki-67 PI differed by subgroups defined by WHO grade and Simpson grade. For patients with the same Simpson grade (1–3), the predictive accuracy of Ki-67 PI for 10-year recurrence risk was stronger in WHO-2 than in WHO-1. Within WHO-1 and WHO-2 meningiomas, the predictive accuracy of Ki-67 PI increased with higher Simpson grade (1–3). However, no predictive value was observed in Simpson grade 4 resections regardless of WHO grade.

Conclusion

These findings highlight that Ki-67 PI should be interpreted in the context of both WHO grade and extent of resection, and, if done so, may offer potential value to refine individualized surveillance strategies in meningioma patients with gross total resection in the initial 10-year postoperative timeframe. Findings cannot be extrapolated beyond 10 years, which may be particularly relevant for WHO-1 tumors with low Ki-67 PI and Simpson grade 1 resection.