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<p> A high-performance, flexible surface-enhanced Raman scattering (SERS) sensing platform designed to detect key hyperuricemia (HUA) biomarkers in non-invasive biofluids is presented. The platform employs a bimetallic nanocomposite hydrogel fabricated via a semi-interpenetrating polymer network, wherein hydroxyethyl cellulose-stabilized gold nanorods are integrated with in situ–reduced silver nanoparticles from oxidized sodium alginate within a sodium alginate/polyacrylamide hybrid network. The hydrogel SERS substrate exhibits outstanding mechanical properties with a tensile strain of up to 911.37% and excellent swelling behavior, achieving equilibrium swelling ratios of 1919.74% in deionized water and 1822.97% in artificial urine. It achieves detection limits of 2.09 × 10<sup>− 10</sup> M for uric acid, 1.70 × 10<sup>− 10</sup> M for xanthine, and 2.14 × 10<sup>− 9</sup> M for hypoxanthine. Spike-and-recovery experiments in artificial urine confirm recoveries consistently above 90%, validating the substrate’s excellent accuracy and reproducibility in complex biological matrices. Collectively, this work provides a novel and reliable approach for advancing non-invasive, real-time monitoring of HUA.</p> Graphical abstract <p></p>

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Non-invasive monitoring of hyperuricemia via a flexible SERS sensor with ultrahigh sensitivity

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Shurui Chen,
  • Jiachen Weng,
  • Hao Chang,
  • Kaiming Xiao,
  • Yaling Wu,
  • Yudong Lu,
  • Ruiyun You

摘要

A high-performance, flexible surface-enhanced Raman scattering (SERS) sensing platform designed to detect key hyperuricemia (HUA) biomarkers in non-invasive biofluids is presented. The platform employs a bimetallic nanocomposite hydrogel fabricated via a semi-interpenetrating polymer network, wherein hydroxyethyl cellulose-stabilized gold nanorods are integrated with in situ–reduced silver nanoparticles from oxidized sodium alginate within a sodium alginate/polyacrylamide hybrid network. The hydrogel SERS substrate exhibits outstanding mechanical properties with a tensile strain of up to 911.37% and excellent swelling behavior, achieving equilibrium swelling ratios of 1919.74% in deionized water and 1822.97% in artificial urine. It achieves detection limits of 2.09 × 10− 10 M for uric acid, 1.70 × 10− 10 M for xanthine, and 2.14 × 10− 9 M for hypoxanthine. Spike-and-recovery experiments in artificial urine confirm recoveries consistently above 90%, validating the substrate’s excellent accuracy and reproducibility in complex biological matrices. Collectively, this work provides a novel and reliable approach for advancing non-invasive, real-time monitoring of HUA.

Graphical abstract