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<p>A novel integrated ion source component based on molecularly imprinted polymer-coated metal-organic cages (SSS@MOC@MIP) was developed for rapid aflatoxin (AFs) detection via ambient mass spectrometry (AMS). By leveraging the synergistic effects of a high-surface-area MOC scaffold which endows the material with exceptional adsorption capacity and specific imprinted cavities, this integrated probe enables simultaneous enrichment, purification, and ionization on a single device. The method effectively suppressed severe matrix interferences from peanut oil and corn starch (matrix effects within ± 15.3%) and achieved a high imprinting factor of 3.27. Under optimized conditions, the SSS@MOC@MIP-AMS method allowed for rapid quantification within 1&#xa0;min, with low limits of detection (0.11–0.54&#xa0;µg/kg) and satisfactory recoveries (79.05%–108.29%), and excellent precision with relative standard deviations (RSDs) less than 14.63%. The probe exhibited robust reusability for at least six cycles. Practical application to commercial samples confirmed its reliability, offering a powerful and high-throughput tool for the rapid screening of trace-level aflatoxins in complex food matrices.</p> Graphical abstract <p></p>

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Molecularly imprinted polymer-coated metal-organic cages as ambient ionization probes for rapid detection of aflatoxins in peanut and corn

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Yulong Ren,
  • Rui Ao,
  • XiuJuan Wang,
  • Jie Lian,
  • Xiu-Li Xu

摘要

A novel integrated ion source component based on molecularly imprinted polymer-coated metal-organic cages (SSS@MOC@MIP) was developed for rapid aflatoxin (AFs) detection via ambient mass spectrometry (AMS). By leveraging the synergistic effects of a high-surface-area MOC scaffold which endows the material with exceptional adsorption capacity and specific imprinted cavities, this integrated probe enables simultaneous enrichment, purification, and ionization on a single device. The method effectively suppressed severe matrix interferences from peanut oil and corn starch (matrix effects within ± 15.3%) and achieved a high imprinting factor of 3.27. Under optimized conditions, the SSS@MOC@MIP-AMS method allowed for rapid quantification within 1 min, with low limits of detection (0.11–0.54 µg/kg) and satisfactory recoveries (79.05%–108.29%), and excellent precision with relative standard deviations (RSDs) less than 14.63%. The probe exhibited robust reusability for at least six cycles. Practical application to commercial samples confirmed its reliability, offering a powerful and high-throughput tool for the rapid screening of trace-level aflatoxins in complex food matrices.

Graphical abstract