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<p>Sensitive, non-invasive detection of the steroid hormone cortisol aids in preventing chronic diseases such as depression and anxiety caused by stress. This study presents the development of a novel sweat cortisol sensor, integrating core-shell structured molecularly imprinted polymer (MIP) nanoparticles with a three-dimensional conductive aerogel to enable efficient, non-invasive monitoring of stress-related cortisol levels. This sensor leverages the large specific surface area and conductive network of aerogel to enhance electron transport efficiency and sensor sensitivity. The MIP nanoparticles are engineered with a gold nanoparticle-modified Prussian blue analogue core, providing stable redox activity and optimizing electrochemical performance. The sensor exhibits an extensive detection range from 10 pM to 100 µM and a remarkably low detection limit of 4.36 × 10<sup>− 12</sup> M, alongside selectivity against other interfering substances. Screen printing technology was employed to fabricate the sensor into a wearable form, validating its stable detection performance and paving the way for mass production and practical applications. This research effectively addresses the limitations of conventional cortisol detection methods, offering a novel approach for real-time dynamic monitoring of stress-related physiological indicators, with significant implications for mental health surveillance and disease prevention.</p> Graphical Abstract <p></p>

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A wearable electrochemical sensor for sweat cortisol detection based on molecularly imprinted polymer nanoparticles and cellulose nanofiber/carbon nanotube conductive aerogel

  • 期刊论文

  • 发表日期：

    2026年5月14日

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  • Zeyu Ming,
  • Xiangchuan Zhao,
  • Changshun Gu,
  • Wenjing Qin,
  • Zhangye Jiang,
  • Xingyue Zhang,
  • Yanli Wang,
  • Shougen Yin

摘要

Sensitive, non-invasive detection of the steroid hormone cortisol aids in preventing chronic diseases such as depression and anxiety caused by stress. This study presents the development of a novel sweat cortisol sensor, integrating core-shell structured molecularly imprinted polymer (MIP) nanoparticles with a three-dimensional conductive aerogel to enable efficient, non-invasive monitoring of stress-related cortisol levels. This sensor leverages the large specific surface area and conductive network of aerogel to enhance electron transport efficiency and sensor sensitivity. The MIP nanoparticles are engineered with a gold nanoparticle-modified Prussian blue analogue core, providing stable redox activity and optimizing electrochemical performance. The sensor exhibits an extensive detection range from 10 pM to 100 µM and a remarkably low detection limit of 4.36 × 10− 12 M, alongside selectivity against other interfering substances. Screen printing technology was employed to fabricate the sensor into a wearable form, validating its stable detection performance and paving the way for mass production and practical applications. This research effectively addresses the limitations of conventional cortisol detection methods, offering a novel approach for real-time dynamic monitoring of stress-related physiological indicators, with significant implications for mental health surveillance and disease prevention.

Graphical Abstract