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<p>Two covalent organic framework&#xa0;(COF) materials—TAPA-TFPB-COF and TAPA-BTT-COF—were synthesized through Schiff-base condensation reactions, and their catalytic performance in the luminol-H<sub>2</sub>O<sub>2</sub> cathodic electrochemiluminescence (ECL) system was systematically investigated. The results demonstrated that TAPA-BTT-COF exhibited superior peroxidase-like activity, which could effectively catalyze the decomposition of H<sub>2</sub>O<sub>2</sub> to generate reactive oxygen species (ROS) and significantly enhance the ECL intensity. Based on this catalytic mechanism, a highly sensitive and selective method for the detection of tyrosine (Tyr) was established, with a linear detection range from 1.0 × 10<sup>− 8</sup> to 1.0 × 10<sup>− 4</sup> mol L<sup>− 1</sup> and a detection limit as low as 6.2 × 10<sup>− 10</sup> mol L<sup>− 1</sup>. This study innovatively explored and utilized the intrinsic enzyme-like activity of COF materials as a substitute for traditional biological enzymes to construct a stable, cost-effective, and ultrasensitive enzyme-free ECL sensing platform, which might further expand the biosensing application of COF materials.</p>

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Promoting effect of peroxidase-like activity covalent organic frameworks on luminol-H2O2 cathodic electroluminescence and its sensing application

  • 期刊论文

  • 发表日期：

    2026年4月25日

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  • Jing Wang,
  • Zihan Fang,
  • Xinyi Wang,
  • Yongping Dong,
  • Houcheng Ding

摘要

Two covalent organic framework (COF) materials—TAPA-TFPB-COF and TAPA-BTT-COF—were synthesized through Schiff-base condensation reactions, and their catalytic performance in the luminol-H2O2 cathodic electrochemiluminescence (ECL) system was systematically investigated. The results demonstrated that TAPA-BTT-COF exhibited superior peroxidase-like activity, which could effectively catalyze the decomposition of H2O2 to generate reactive oxygen species (ROS) and significantly enhance the ECL intensity. Based on this catalytic mechanism, a highly sensitive and selective method for the detection of tyrosine (Tyr) was established, with a linear detection range from 1.0 × 10− 8 to 1.0 × 10− 4 mol L− 1 and a detection limit as low as 6.2 × 10− 10 mol L− 1. This study innovatively explored and utilized the intrinsic enzyme-like activity of COF materials as a substitute for traditional biological enzymes to construct a stable, cost-effective, and ultrasensitive enzyme-free ECL sensing platform, which might further expand the biosensing application of COF materials.