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<p>The development of a bimetallic metal-organic framework (Cu/Co@MOF) is presented using copper and cobalt as central ions and vitamin B<sub>6</sub> as the green ligand through a straightforward microwave digestion technique that act as potent laccase mimics, specifically designed for estrogen (including estriol, estradiol, and diethylstilbestrol) sensing. A newly designed Cu/Co@MOF nanozyme probe exhibits significantly improved laccase-mimicking activity and photothermal efficiency when exposed to near-infrared (NIR) light. Experimental investigations elucidated that NIR promoted the activation of molecular oxygen (O<sub>2</sub>) for generation of producing superoxide radicals (∙O<sub>2</sub><sup>−</sup>) and electron transfer efficiency (Co<sup>3+</sup>/Co<sup>2+</sup>-Cu<sup>+</sup>/Cu<sup>2+</sup>), improving oxygen activation efficiency and catalytic cycling. Under NIR stimulation, the catalytic efficiency of the Cu/Co@MOF nanozyme increases markedly, achieving a four times improvement compared to non-stimulated conditions. Importantly, Cu/Co@MOF maintains impressive stability across a broad pH range and temperatures. The absorbance of estradiol shows a linear correlation with concentrations spanning from 0.02 to 25&#xa0;µg/L, 0.012 to 36&#xa0;µg/L, and 0.045 to 15&#xa0;µg/L, with corresponding detection limits of 0.016&#xa0;µg/L, 0.006&#xa0;µg/L, and 0.038&#xa0;µg/L, respectively. Furthermore, the colorimetric sensor based on Cu/Co@MOF demonstrates outstanding performance in detecting estrogens.</p> Graphical Abstract <p></p>

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Near infrared light enhanced a green vitamin Cu/Co@MOF laccase-like nanozyme activity for estrogen colorimetric detection

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • Xiao Li,
  • Junfeng Fang,
  • Tao Yuan,
  • Lingchuan Li,
  • Yaling Yang,
  • Xiaomei Wu

摘要

The development of a bimetallic metal-organic framework (Cu/Co@MOF) is presented using copper and cobalt as central ions and vitamin B6 as the green ligand through a straightforward microwave digestion technique that act as potent laccase mimics, specifically designed for estrogen (including estriol, estradiol, and diethylstilbestrol) sensing. A newly designed Cu/Co@MOF nanozyme probe exhibits significantly improved laccase-mimicking activity and photothermal efficiency when exposed to near-infrared (NIR) light. Experimental investigations elucidated that NIR promoted the activation of molecular oxygen (O2) for generation of producing superoxide radicals (∙O2−) and electron transfer efficiency (Co3+/Co2+-Cu+/Cu2+), improving oxygen activation efficiency and catalytic cycling. Under NIR stimulation, the catalytic efficiency of the Cu/Co@MOF nanozyme increases markedly, achieving a four times improvement compared to non-stimulated conditions. Importantly, Cu/Co@MOF maintains impressive stability across a broad pH range and temperatures. The absorbance of estradiol shows a linear correlation with concentrations spanning from 0.02 to 25 µg/L, 0.012 to 36 µg/L, and 0.045 to 15 µg/L, with corresponding detection limits of 0.016 µg/L, 0.006 µg/L, and 0.038 µg/L, respectively. Furthermore, the colorimetric sensor based on Cu/Co@MOF demonstrates outstanding performance in detecting estrogens.

Graphical Abstract