Scholarlink

<p>The rapid, on-site quantification of nicotine in mainstream cigarette smoke is important for public health assessment yet poses a significant analytical challenge due to the complex sample matrix. Herein, we report a surface-enhanced Raman scattering (SERS) platform based on Au@Ag spiny spheres, engineered with high-density nanotips that generate intense plasmonic hot spots for sensitive nicotine detection. The platform features a pretreatment-free strategy wherein the Au@Ag colloid serves a dual role as both an in-situ extraction phase and the SERS-active substrate. This integration of sampling and detection yields a 150-fold signal enhancement and a 0.42&#xa0;µg/mL limit of detection, with each analysis completed within 5&#xa0;s. The method’s accuracy was validated across eight commercial cigarette brands, demonstrating excellent agreement with standard gas chromatography (RSD &lt; 3.54%). This work thus provides a practical, field-deployable SERS approach that addresses key limitations of conventional analysis, enabling rapid quantification of public health-relevant chemical exposure.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Au@Ag spiny sphere-based SERS for the ultrasensitive and rapid detection of nicotine in mainstream cigarette smoke

  • 期刊论文

  • 发表日期：

    2026年3月6日

查看全文
  • Xiao Pan,
  • Yu Zhong,
  • Chenshuo Zhao,
  • Zejing Hu,
  • Wenjing Wang,
  • Yingqi Duan,
  • Wenai Guo,
  • Chunpeng Jiao,
  • Jingbin Zeng

摘要

The rapid, on-site quantification of nicotine in mainstream cigarette smoke is important for public health assessment yet poses a significant analytical challenge due to the complex sample matrix. Herein, we report a surface-enhanced Raman scattering (SERS) platform based on Au@Ag spiny spheres, engineered with high-density nanotips that generate intense plasmonic hot spots for sensitive nicotine detection. The platform features a pretreatment-free strategy wherein the Au@Ag colloid serves a dual role as both an in-situ extraction phase and the SERS-active substrate. This integration of sampling and detection yields a 150-fold signal enhancement and a 0.42 µg/mL limit of detection, with each analysis completed within 5 s. The method’s accuracy was validated across eight commercial cigarette brands, demonstrating excellent agreement with standard gas chromatography (RSD < 3.54%). This work thus provides a practical, field-deployable SERS approach that addresses key limitations of conventional analysis, enabling rapid quantification of public health-relevant chemical exposure.

Graphical Abstract