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<p>Ensuring reliable detection in complex sample matrices remains a significant challenge. Dual-mode strategies offering built-in cross-validation present a promising solution. Herein, a miniaturized photoacoustic (PA)-photothermal (PT) dual-mode device was developed by integrating an origami paper-based platform and utilizing oxidized 3,3',5,5'-tetramethylbenzidine (oxTMB) as a signal probe. The CuS/g-C₃N₄ catalyzes the oxidation of colorless TMB into blue oxTMB, which generates strong PA and PT signals under 808&#xa0;nm laser irradiation. Crucially, antioxidants (such as dopamine, ascorbic acid, and glutathione) inhibit the TMB oxidation, leading to a signal decrease. With a small sample volume of 15 μL and an analysis time of 30 min, the device demonstrated excellent stability, reproducibility, and accuracy. Its practical applicability was validated by the successful analysis of various real food samples. Overall, this work presents a novel dual-mode device that enables cross-validation and holds great potential for on-site food safety detection.</p> Graphical abstract <p></p>

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Portable origami paper-based photoacoustic-photothermal dual-mode device for on-site antioxidants detection

  • 期刊论文

  • 发表日期：

    2026年1月29日

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  • Yajie Zhang,
  • Zixuan Guo,
  • Yuxi Qin,
  • Xiaohui Zhang,
  • Baiyan Zhang,
  • Ruiping Zhang,
  • Yunlan Li

摘要

Ensuring reliable detection in complex sample matrices remains a significant challenge. Dual-mode strategies offering built-in cross-validation present a promising solution. Herein, a miniaturized photoacoustic (PA)-photothermal (PT) dual-mode device was developed by integrating an origami paper-based platform and utilizing oxidized 3,3',5,5'-tetramethylbenzidine (oxTMB) as a signal probe. The CuS/g-C₃N₄ catalyzes the oxidation of colorless TMB into blue oxTMB, which generates strong PA and PT signals under 808 nm laser irradiation. Crucially, antioxidants (such as dopamine, ascorbic acid, and glutathione) inhibit the TMB oxidation, leading to a signal decrease. With a small sample volume of 15 μL and an analysis time of 30 min, the device demonstrated excellent stability, reproducibility, and accuracy. Its practical applicability was validated by the successful analysis of various real food samples. Overall, this work presents a novel dual-mode device that enables cross-validation and holds great potential for on-site food safety detection.

Graphical abstract