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Abstract <p>Norfloxacin (NFX) residues in food and environmental samples threaten human health, necessitating rapid on-site detection. A hierarchical MOF@MOF probe (Ag-MOF-74/NH₂-MIL-53(Al) for ratiometric NFX sensing has been fabricated, in which NH₂-MIL-53(Al) enhances NFX emission via hydrogen bonding and energy transfer, while Ag-MOF-74 provides a stable reference, enabling self-calibration. The probe can not only achieve ultrasensitive detection within 75&#xa0;s, but also exhibits a low limit of detection (LOD), high selectivity and good reproducibility. A smartphone-based platform was designed for on-site quantification within minutes. Validated in milk, soil, and water, it showed excellent accuracy (98–102% recovery) and precision (RSD &lt; 2.86%). This MOF@MOF strategy offers a robust on-site screening tool and a versatile design paradigm for food safety and environmental monitoring.</p> Graphical Abstract <p></p>

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Hierarchical MOF@MOF ratiometric fluorescent probe for ultrasensitive on-site detection of norfloxacin in food and environmental samples

  • 期刊论文

  • 发表日期：

    2025年10月28日

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  • Xinlou Li,
  • Ganghui Wang,
  • Haoxiang Wang,
  • Aijia Wang,
  • Hongxu Guo

摘要

Abstract

Norfloxacin (NFX) residues in food and environmental samples threaten human health, necessitating rapid on-site detection. A hierarchical MOF@MOF probe (Ag-MOF-74/NH₂-MIL-53(Al) for ratiometric NFX sensing has been fabricated, in which NH₂-MIL-53(Al) enhances NFX emission via hydrogen bonding and energy transfer, while Ag-MOF-74 provides a stable reference, enabling self-calibration. The probe can not only achieve ultrasensitive detection within 75 s, but also exhibits a low limit of detection (LOD), high selectivity and good reproducibility. A smartphone-based platform was designed for on-site quantification within minutes. Validated in milk, soil, and water, it showed excellent accuracy (98–102% recovery) and precision (RSD < 2.86%). This MOF@MOF strategy offers a robust on-site screening tool and a versatile design paradigm for food safety and environmental monitoring.

Graphical Abstract