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<p>Hollow covalent organic framework (HCOF) with a well-ordered pore structure can provide a robust platform for the anchoring of metal nanoparticles to design an innovative and potent nanozyme. Herein, an amorphous-to-crystalline transition strategy was utilized to synthesize the uniform HCOF, which was used as an effective nanocarrier for the anchoring of Cu-Ni bimetallic nanoparticles to prepare Cu-Ni/HCOF nanozyme with laccase-mimicking activity. By integrating the morphological control of amorphous covalent organic polymer (COP) and the crystallization-induced hollowing out, the synthesized HCOF increased the substrate enrichment and diffusion, super-adding the massive loading of Cu-Ni nanoparticles, which significantly promoted the catalytic activity. Taking advantage of the laccase-mimicking activity of the Cu-Ni/HCOF nanozyme, simple and efficient detection of epinephrine was achieved with a detection limit of 0.14 µg/mL. This colorimetric sensing strategy offered an efficient approach for epinephrine detection in a complex matrix, exhibiting potential application in the early diagnosis of disease.</p> Graphical Abstract <p></p>

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Amorphous-to-crystalline transition strategy boosting copper-nickel bimetallic anchored hollow covalent organic framework nanozyme for colorimetric sensing of epinephrine

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Ran Na,
  • Yuying Yuan,
  • Ziyi Yang,
  • Jianliang Chen,
  • Yixi Gu,
  • Ting Bao,
  • Xiuhua Zhang,
  • Shengfu Wang,
  • Wei Wen

摘要

Hollow covalent organic framework (HCOF) with a well-ordered pore structure can provide a robust platform for the anchoring of metal nanoparticles to design an innovative and potent nanozyme. Herein, an amorphous-to-crystalline transition strategy was utilized to synthesize the uniform HCOF, which was used as an effective nanocarrier for the anchoring of Cu-Ni bimetallic nanoparticles to prepare Cu-Ni/HCOF nanozyme with laccase-mimicking activity. By integrating the morphological control of amorphous covalent organic polymer (COP) and the crystallization-induced hollowing out, the synthesized HCOF increased the substrate enrichment and diffusion, super-adding the massive loading of Cu-Ni nanoparticles, which significantly promoted the catalytic activity. Taking advantage of the laccase-mimicking activity of the Cu-Ni/HCOF nanozyme, simple and efficient detection of epinephrine was achieved with a detection limit of 0.14 µg/mL. This colorimetric sensing strategy offered an efficient approach for epinephrine detection in a complex matrix, exhibiting potential application in the early diagnosis of disease.

Graphical Abstract