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<p>Ciprofloxacin (CIP), a third-generation fluoroquinolone antibiotic, exhibits broad-spectrum antibacterial activity and is widely used in clinical and veterinary practice. However, long-term exposure to CIP poses potential health risks to living organisms. Leveraging its efficient fluorescence quenching effect on coumarin derivatives, a highly sensitive fluorescent probe (CD@ZIF-8) was developed by encapsulating a coumarin derivative within a zeolitic imidazolate framework-8 (ZIF-8) matrix. Fluorescence emission peaks of the CD@ZIF-8 located at 505&#xa0;nm when the excitation wavelength was 450&#xa0;nm. This fluorescent probe was developed for the quantitative detection of CIP. The inner filter effect (IFE) was identified as the primary quenching mechanism. The detection limit for CIP was 58.9&#xa0;nM, with a relative standard deviation (RSD) not exceeding 3.0%. Satisfactory recoveries ranging from 99.75% to 112.19% demonstrate the good accuracy of CD@ZIF-8 for CIP detection. The sensor exhibits excellent stability, high selectivity, and strong anti-interference capability, thus providing a promising strategy for highly sensitive detection of CIP with potential applications in safeguarding human health and ensuring food safety.</p> Graphical Abstract <p></p>

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High sensitivity determination of ciprofloxacin by fluorescence sensor based on encapsulation of coumarin derivative with ZIF-8

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • Qihui Wang,
  • Fan Yang,
  • Luojia Xiong,
  • Chendi Li,
  • Zihang He,
  • Jiexue Wang,
  • Kang Sun,
  • Guowei Deng

摘要

Ciprofloxacin (CIP), a third-generation fluoroquinolone antibiotic, exhibits broad-spectrum antibacterial activity and is widely used in clinical and veterinary practice. However, long-term exposure to CIP poses potential health risks to living organisms. Leveraging its efficient fluorescence quenching effect on coumarin derivatives, a highly sensitive fluorescent probe (CD@ZIF-8) was developed by encapsulating a coumarin derivative within a zeolitic imidazolate framework-8 (ZIF-8) matrix. Fluorescence emission peaks of the CD@ZIF-8 located at 505 nm when the excitation wavelength was 450 nm. This fluorescent probe was developed for the quantitative detection of CIP. The inner filter effect (IFE) was identified as the primary quenching mechanism. The detection limit for CIP was 58.9 nM, with a relative standard deviation (RSD) not exceeding 3.0%. Satisfactory recoveries ranging from 99.75% to 112.19% demonstrate the good accuracy of CD@ZIF-8 for CIP detection. The sensor exhibits excellent stability, high selectivity, and strong anti-interference capability, thus providing a promising strategy for highly sensitive detection of CIP with potential applications in safeguarding human health and ensuring food safety.

Graphical Abstract