Scholarlink

<p> A&#xa0;novel CuPd@GOF nanocomposite&#xa0;is introduced, where copper and palladium nanoparticles (∼2&#xa0;nm) are encapsulated within a three-dimensional graphene oxide framework (GOF), enabling superior catalytic performance. The rigid GOF structure ensures high nanoparticle dispersion, Maximizing atom utilization and catalytic efficiency. Additionally, Cu incorporation enhances activity through Fenton-like catalysis while reducing Material costs. The nanocomposite possesses a 2.72&#xa0;eV bandgap, facilitating light harvesting ability for photocatalysis. CuPd@GOF exhibits dual enzyme-mimetic activities: a superior peroxidase-mimic activity, surpassing monometallic Cu@GOF and Pd@GOF, and an oxidase-mimic activity under external light irradiation. The peroxidase-mimic activity of this novel nanocomposite was exploited for uricase-free colorimetric detection of uric acid (UA), a key biomarker for gout and kidney disorders. The colorimetric assay utilizes Cu-mediated urate complexation and π–π interactions for enzyme-free detection, achieving a detection Limit of 12.62&#xa0;µM with a broad linear range (5–100&#xa0;µM) within 10&#xa0;min. The method exhibits good selectivity against biological interferents and was successfully validated using fetal bovine serum, demonstrating its potential for biomedical applications.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dual enzyme-mimetic activity of graphene oxide framework encapsulated copper-palladium bimetallic nanoparticles for uricase-free colorimetric detection of uric acid

  • 期刊论文

  • 发表日期：

    2025年9月24日

查看全文
  • Diksha J. Baruah,
  • Pulakesh Borah,
  • Ashutosh Thakur,
  • Manash R. Das

摘要

A novel CuPd@GOF nanocomposite is introduced, where copper and palladium nanoparticles (∼2 nm) are encapsulated within a three-dimensional graphene oxide framework (GOF), enabling superior catalytic performance. The rigid GOF structure ensures high nanoparticle dispersion, Maximizing atom utilization and catalytic efficiency. Additionally, Cu incorporation enhances activity through Fenton-like catalysis while reducing Material costs. The nanocomposite possesses a 2.72 eV bandgap, facilitating light harvesting ability for photocatalysis. CuPd@GOF exhibits dual enzyme-mimetic activities: a superior peroxidase-mimic activity, surpassing monometallic Cu@GOF and Pd@GOF, and an oxidase-mimic activity under external light irradiation. The peroxidase-mimic activity of this novel nanocomposite was exploited for uricase-free colorimetric detection of uric acid (UA), a key biomarker for gout and kidney disorders. The colorimetric assay utilizes Cu-mediated urate complexation and π–π interactions for enzyme-free detection, achieving a detection Limit of 12.62 µM with a broad linear range (5–100 µM) within 10 min. The method exhibits good selectivity against biological interferents and was successfully validated using fetal bovine serum, demonstrating its potential for biomedical applications.

Graphical Abstract