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<p> An electrochemical sensor (ITO-AuNPs-cys-Ag) for the determination of hypochorite (ClO<sup>-</sup>)&#xa0;was constructed, where Au nanoparticles (AuNPs) serve as the substrate and Ag<sup>+</sup> acts as the signal probe, interconnected via cysteamine (cys) through Au–S and Ag–N bonds. The disruption of the Ag–N coordination bond by ClO<sup>−</sup> causes the detachment of Ag<sup>+</sup> from the sensing interface, resulting in a decrease in the electrochemical signal. A wide linear range of 0.75–25&#xa0;μM and a low limit of detection (LOD) of 0.53&#xa0;μM were obtained with the sensor. The used sensor can be regenerated by incubation in a AgNO<sub>3</sub> solution. Further study revealed that Ag<sup>+</sup> plays a critical role in preventing the interferences from other highly oxidative reactive oxygen species&#xa0;(ROS) in samples; thus, the prepared sensor can be directly applied to the determination of ClO<sup>−</sup> in environment samples and ferroptosis of NIH3T3 cells. The results obtained not only provide a useful sensor for exploration of the reaction processes and physiological pathways of ClO<sup>−</sup>, but also demonstrate a new strategy to improve the selectivity of electrochemical sensors.</p> Graphical Abstract <p></p>

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Silver-mediated electrochemical sensor for rapid determination of hypochlorite in the coexistence of ROS

  • 期刊论文

  • 发表日期：

    2025年7月24日

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  • Haining Cui,
  • Xiaoyuan Zheng,
  • Jinxin Ma,
  • Youyi Liu,
  • Chan Wang,
  • Qijun Song

摘要

An electrochemical sensor (ITO-AuNPs-cys-Ag) for the determination of hypochorite (ClO-) was constructed, where Au nanoparticles (AuNPs) serve as the substrate and Ag+ acts as the signal probe, interconnected via cysteamine (cys) through Au–S and Ag–N bonds. The disruption of the Ag–N coordination bond by ClO− causes the detachment of Ag+ from the sensing interface, resulting in a decrease in the electrochemical signal. A wide linear range of 0.75–25 μM and a low limit of detection (LOD) of 0.53 μM were obtained with the sensor. The used sensor can be regenerated by incubation in a AgNO3 solution. Further study revealed that Ag+ plays a critical role in preventing the interferences from other highly oxidative reactive oxygen species (ROS) in samples; thus, the prepared sensor can be directly applied to the determination of ClO− in environment samples and ferroptosis of NIH3T3 cells. The results obtained not only provide a useful sensor for exploration of the reaction processes and physiological pathways of ClO−, but also demonstrate a new strategy to improve the selectivity of electrochemical sensors.

Graphical Abstract