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<p>Various analytical techniques are available for the detection of antituberculosis drug delamanid (DLM), whose unregulated dosage can lead to severe health issues. To date, electrochemical sensing of delamanid remains unexplored. In this work, we demonstrate that niobium pentoxide (Nb<sub>2</sub>O<sub>5</sub>)/aluminum metal organic framework (Al MOF) nanocomposite is synthesized and incorporated into hydrogel-derived foam (Nb<sub>2</sub>O<sub>5</sub>/Al MOF/HFF) for electrochemical sensing of DLM. Nb<sub>2</sub>O<sub>5</sub>/Al MOF nanocomposite is synthesized using the hydrothermal method, and Nb<sub>2</sub>O<sub>5</sub>/Al MOF/HFF is synthesized by freeze-drying followed by lyophilization. Field emission scanning electron microscopy (FESEM) micrograph reveals successful nanocomposite formation, where Nb<sub>2</sub>O<sub>5</sub> nanoparticles are anchored at the edges of rod-like platelet Al MOF. X-ray diffraction (XRD) confirms the crystallinity of Nb<sub>2</sub>O<sub>5</sub>/Al MOF incorporated in HFF. Cyclic voltammetry reveals an enhancement in the electrochemical activity of Nb<sub>2</sub>O<sub>5</sub>/Al MOF/HFF due to the electrocatalytic activity of Nb<sup>5+</sup>/Nb<sup>4+</sup>. Using Nb<sub>2</sub>O<sub>5</sub>/Al MOF/HFF, electrochemical sensing of DLM is achieved in a linear detection range of 1&#xa0;nM to 20&#xa0;µM. Sensitivity of Nb<sub>2</sub>O<sub>5</sub>/Al MOF HFF towards DLM is 0.26&#xa0;nM/µA and exhibits a limit of detection (LOD) of 0.83&#xa0;nM and limit of quantification (LOQ) of 1.58&#xa0;nM. The as-fabricated sensor leverages the synergistic effect between redox-active Nb<sub>2</sub>O<sub>5</sub> and the porous architecture of Al-MOF to achieve enhanced electrocatalytic performance. Incorporation of Nb<sub>2</sub>O<sub>5</sub> contributes to improved electron transfer kinetics and catalytic activity, while Al-MOF serves as active sites. Notably, HFF offers mechanical flexibility and interconnected pathways for electrolyte diffusion, thereby improving sensitivity and reproducibility. The sensor exhibits outstanding selectivity towards delamanid in the presence of interferents. The sensor’s excellent sensitivity, selectivity, and reproducibility make it suitable for integration into wearable diagnostics and flexible electrochemical sensors.</p> Graphical abstract <p></p>

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Flexible, self-standing 3D Nb2O5/Al MOF embedded hydrogel-derived foam: an efficient electrode for electrochemical sensing of the antituberculosis drug delamanid in biological fluids

  • 期刊论文

  • 发表日期：

    2025年6月26日

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  • Divyasri Ramasamy,
  • Sushmee Badhulika

摘要

Various analytical techniques are available for the detection of antituberculosis drug delamanid (DLM), whose unregulated dosage can lead to severe health issues. To date, electrochemical sensing of delamanid remains unexplored. In this work, we demonstrate that niobium pentoxide (Nb2O5)/aluminum metal organic framework (Al MOF) nanocomposite is synthesized and incorporated into hydrogel-derived foam (Nb2O5/Al MOF/HFF) for electrochemical sensing of DLM. Nb2O5/Al MOF nanocomposite is synthesized using the hydrothermal method, and Nb2O5/Al MOF/HFF is synthesized by freeze-drying followed by lyophilization. Field emission scanning electron microscopy (FESEM) micrograph reveals successful nanocomposite formation, where Nb2O5 nanoparticles are anchored at the edges of rod-like platelet Al MOF. X-ray diffraction (XRD) confirms the crystallinity of Nb2O5/Al MOF incorporated in HFF. Cyclic voltammetry reveals an enhancement in the electrochemical activity of Nb2O5/Al MOF/HFF due to the electrocatalytic activity of Nb5+/Nb4+. Using Nb2O5/Al MOF/HFF, electrochemical sensing of DLM is achieved in a linear detection range of 1 nM to 20 µM. Sensitivity of Nb2O5/Al MOF HFF towards DLM is 0.26 nM/µA and exhibits a limit of detection (LOD) of 0.83 nM and limit of quantification (LOQ) of 1.58 nM. The as-fabricated sensor leverages the synergistic effect between redox-active Nb2O5 and the porous architecture of Al-MOF to achieve enhanced electrocatalytic performance. Incorporation of Nb2O5 contributes to improved electron transfer kinetics and catalytic activity, while Al-MOF serves as active sites. Notably, HFF offers mechanical flexibility and interconnected pathways for electrolyte diffusion, thereby improving sensitivity and reproducibility. The sensor exhibits outstanding selectivity towards delamanid in the presence of interferents. The sensor’s excellent sensitivity, selectivity, and reproducibility make it suitable for integration into wearable diagnostics and flexible electrochemical sensors.

Graphical abstract