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<p>Kaempferol (KA), a natural polyphenolic compound with potent anti-cancer activity and pharmacological benefits, exhibits dose-dependent toxicity upon excessive intake. In this work, the MoO<sub>2</sub>@N–C/PC-800 composite was synthesized to overcome the application limitations of single-component transition metal oxides, effectively enhancing the reduction current signal during the electrochemical detection of KA. Notably, combined SEM/TEM/XPS analyses demonstrate that the composite’s hierarchical crumpled architecture exposes abundant electroactive sites, thereby achieving superior sensing performance. The sensor constructed based on MoO<sub>2</sub>@N–C/PC-800 exhibited a broad detection range of 0.01–30 μM for KA with an ultralow limit of detection (LOD) of 9.8 nM. To validate the reliability of electrochemical sensing results, UV–Vis was employed as a reference method for comparative analysis of&#xa0; real samples. The sensor’s KA concentration measurements were cross-validated against UV–Vis-determined values, yielding recoveries&#xa0; of 95.5–106.0% and relative standard deviation (RSD) values of 1.12–2.29%, which demonstrate excellent consistency between the two methods.</p> Graphical Abstract <p></p>

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Pomelo peel-derived porous carbon-supported MoO2@N–C nanoflowers: synergistic amplification for sensitive sensing of kaempferol

  • 期刊论文

  • 发表日期：

    2025年6月3日

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  • Le Liu,
  • Maoheng Fei,
  • Yilin Wang,
  • Zhifang Liu,
  • Ying Tang,
  • Xinyi Li,
  • Yixi Xie,
  • Pengcheng Zhao,
  • Junjie Fei

摘要

Kaempferol (KA), a natural polyphenolic compound with potent anti-cancer activity and pharmacological benefits, exhibits dose-dependent toxicity upon excessive intake. In this work, the MoO2@N–C/PC-800 composite was synthesized to overcome the application limitations of single-component transition metal oxides, effectively enhancing the reduction current signal during the electrochemical detection of KA. Notably, combined SEM/TEM/XPS analyses demonstrate that the composite’s hierarchical crumpled architecture exposes abundant electroactive sites, thereby achieving superior sensing performance. The sensor constructed based on MoO2@N–C/PC-800 exhibited a broad detection range of 0.01–30 μM for KA with an ultralow limit of detection (LOD) of 9.8 nM. To validate the reliability of electrochemical sensing results, UV–Vis was employed as a reference method for comparative analysis of  real samples. The sensor’s KA concentration measurements were cross-validated against UV–Vis-determined values, yielding recoveries  of 95.5–106.0% and relative standard deviation (RSD) values of 1.12–2.29%, which demonstrate excellent consistency between the two methods.

Graphical Abstract