Scholarlink

<p>Abnormal lipid droplet accumulation and metabolism can precipitate various diseases. Understanding the dynamics of intracellular lipid droplets, particularly hypochlorite acid (HOCl) and polarity, is crucial for elucidating the onset and progression of these diseases. In this study, we synthesized a near-infrared fluorescent probe, <b>NSSP</b>, featuring a D-π-A structure, which facilitates the independent dual-response detection of HOCl and polarity. <b>NSSP</b> not only reveals the polarity and HOCl fluctuations in inflammatory cells and inflammation in live mice but also differentiates between normal and fatty liver tissues through two distinct channels. Furthermore, the probe has proven effective in identifying neoplasms within live murine models at both the cellular and systemic levels, thereby affirming its utility as an instrumental resource for the precocious detection of carcinomas. This offers a hopeful avenue for the diagnostic scrutiny of pathologies.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A dual-channel lipid droplet-targeting probe for the detection of polarity and HOCl in models of NAFLD, inflammation, and cancer

  • 期刊论文

  • 发表日期：

    2025年4月25日

查看全文
  • Tingting Yang,
  • Shiyu Yin,
  • Huina Liu,
  • Shunyi Wang,
  • Chengqi Wang,
  • Yuxin Chen,
  • Xiaoya Liu,
  • Fangke Zhu,
  • Jiaxuan Guo,
  • Lajiatai,
  • Dongzhi Suonanmu,
  • Qingjia Ren,
  • Shenghua Liao,
  • Caolong Li

摘要

Abnormal lipid droplet accumulation and metabolism can precipitate various diseases. Understanding the dynamics of intracellular lipid droplets, particularly hypochlorite acid (HOCl) and polarity, is crucial for elucidating the onset and progression of these diseases. In this study, we synthesized a near-infrared fluorescent probe, NSSP, featuring a D-π-A structure, which facilitates the independent dual-response detection of HOCl and polarity. NSSP not only reveals the polarity and HOCl fluctuations in inflammatory cells and inflammation in live mice but also differentiates between normal and fatty liver tissues through two distinct channels. Furthermore, the probe has proven effective in identifying neoplasms within live murine models at both the cellular and systemic levels, thereby affirming its utility as an instrumental resource for the precocious detection of carcinomas. This offers a hopeful avenue for the diagnostic scrutiny of pathologies.

Graphical Abstract