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<p>Systemic inflammatory response syndrome (SIRS) poses a serious threat that influences patient survival and life&#xa0;quality. Its early and accurate diagnosis is paramount in clinics, where procalcitonin (PCT) is recognized as a key serological biomarker. Herein, well-dispersed PtPdCo nanoalloy was efficiently anchored on hollow porous N-doped carbon fibers (termed PtPdCo HPCNFs) through a sequential process involving electrospinning, pyrolysis, etching, and co-reduction. The morphology, structure, and physicochemical properties of PtPdCo HPCNFs&#xa0;were characterized by a set of techniques. Subsequently, the synthesized PtPdCo HPCNF nanocomposite was applied to build a label-free electrochemical amperometric immunosensor for ultrasensitive detection of PCT. Its performance was evaluated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). Notably, the biosensor demonstrated a wide dynamic linear range (0.0001–1000&#xa0;ng&#xa0;mL<sup>−1</sup>) and a low detection limit (0.20&#xa0;pg&#xa0;mL<sup>−1</sup>). Furthermore, the sensor achieved the bioassay of PCT in clinical samples, yielding acceptable results. This work offers a promising approach for synthesizing superior nanomaterials for bioanalytical applications, highlighting their potential in development of sensing devices, especially for early and sensitive diagnosis of SIRS through PCT detection.</p> Graphical abstract <p></p>

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Trimetallic PtPdCo nanoalloy on hollow porous N-doped carbon fibers: A high-performance electrochemical immunosensor for procalcitonin detection in SIRS diagnosis

  • 期刊论文

  • 发表日期：

    2025年3月24日

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  • Yan-Yu Shi,
  • Yu-Lin Zhong,
  • Ai-Jun Wang,
  • Li-Ping Mei,
  • Pei Song,
  • Tiejun Zhao,
  • Jiu-Ju Feng

摘要

Systemic inflammatory response syndrome (SIRS) poses a serious threat that influences patient survival and life quality. Its early and accurate diagnosis is paramount in clinics, where procalcitonin (PCT) is recognized as a key serological biomarker. Herein, well-dispersed PtPdCo nanoalloy was efficiently anchored on hollow porous N-doped carbon fibers (termed PtPdCo HPCNFs) through a sequential process involving electrospinning, pyrolysis, etching, and co-reduction. The morphology, structure, and physicochemical properties of PtPdCo HPCNFs were characterized by a set of techniques. Subsequently, the synthesized PtPdCo HPCNF nanocomposite was applied to build a label-free electrochemical amperometric immunosensor for ultrasensitive detection of PCT. Its performance was evaluated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). Notably, the biosensor demonstrated a wide dynamic linear range (0.0001–1000 ng mL−1) and a low detection limit (0.20 pg mL−1). Furthermore, the sensor achieved the bioassay of PCT in clinical samples, yielding acceptable results. This work offers a promising approach for synthesizing superior nanomaterials for bioanalytical applications, highlighting their potential in development of sensing devices, especially for early and sensitive diagnosis of SIRS through PCT detection.

Graphical abstract