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<p>A&#xa0;cost-effective strategy is reported&#xa0;utilizing ionic liquid (IL), 1-hexyl-3-methylimidazolium bisulfate (<i>[HMIM]</i><sup>+</sup> <i>HSO</i><sub><i>4</i></sub><sup><i>−</i></sup>), to delaminate Ti<sub>3</sub>C<sub>2</sub> MXene, thereby enhancing its efficiency in electrocatalyzing tryptophan (Trp) oxidation. The positively charged IL effectively intercalates within the negatively charged MXene layers, fostering structural stability through π–π stacking and electrostatic interactions. Consequently, the resulting IL-Ti<sub>3</sub>C<sub>2</sub> composite not only maintained the inherent electronic conductivity of Ti<sub>3</sub>C<sub>2</sub> but also significantly augmented its electrocatalytic prowess. The IL-Ti<sub>3</sub>C<sub>2</sub>/GCE sensor highlighted performances, featuring wide dynamic range (0.005 to 1 µM and 1 to 300 µM), low detection limit (0.1 nM), high reproducibility, excellent anti-interference performance, and long-term stability. The exceptional abilities of the IL-Ti<sub>3</sub>C<sub>2</sub> nanocatalyst make it as a very promising electrode material for achieving precise Trp detection in serum samples from both healthy individuals and breast cancer patients, yielding satisfactory result that underscore its potential for clinical applications.</p> Graphical abstract <p></p>

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Ionic liquid-delaminated Ti3C2 MXene nanosheets for enhanced electrocatalytic oxidation of tryptophane in normal and breast cancer serum

  • 期刊论文

  • 发表日期：

    2025年1月30日

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  • Seyyed Mehdi Khoshfetrat,
  • Mohana Nabavi,
  • Saba Mamivand,
  • Zhenyu Wang,
  • Zonghua Wang,
  • Mehdi Hosseini

摘要

A cost-effective strategy is reported utilizing ionic liquid (IL), 1-hexyl-3-methylimidazolium bisulfate ([HMIM]+ HSO4−), to delaminate Ti3C2 MXene, thereby enhancing its efficiency in electrocatalyzing tryptophan (Trp) oxidation. The positively charged IL effectively intercalates within the negatively charged MXene layers, fostering structural stability through π–π stacking and electrostatic interactions. Consequently, the resulting IL-Ti3C2 composite not only maintained the inherent electronic conductivity of Ti3C2 but also significantly augmented its electrocatalytic prowess. The IL-Ti3C2/GCE sensor highlighted performances, featuring wide dynamic range (0.005 to 1 µM and 1 to 300 µM), low detection limit (0.1 nM), high reproducibility, excellent anti-interference performance, and long-term stability. The exceptional abilities of the IL-Ti3C2 nanocatalyst make it as a very promising electrode material for achieving precise Trp detection in serum samples from both healthy individuals and breast cancer patients, yielding satisfactory result that underscore its potential for clinical applications.

Graphical abstract