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<p>A&#xa0;smartphone-based non-invasive method was developed&#xa0;for salivary uric acid detection using <i>Gleditsia Sinensis</i> carbon dots (GS-CDs). The GS-CDs synthesized by the one-pot hydrothermal method emitted blue fluorescence at a maximum excitation wavelength of 350&#xa0;nm and had good fluorescence stability in the presence of different ions, while showing selectivity to uric acid solution. The ability of uric acid&#xa0;(UA) to quench the fluorescent substances present in the GS-CDs, was confirmed through HPLC-FLD and LC–MS, FTIR and XPS. The results showed that UA reacted with GS-CDs, with a decrease in hydroxyl groups and the formation of carboxyl groups. The fluorescence quenching suggested a possible dynamic quenching mechanism. In addition, a smartphone-based non-invasive detection method was developed for the detection of salivary UA levels, which reflects blood UA levels. This study provides a new perspective on the utilization of GS shells and advances the development of non-invasive testing for UA.</p> Graphical Abstract <p></p>

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Smartphone-based non-invasive detection of salivary uric acid based on the fluorescence quenching of gleditsia sinensis carbon dots

  • 期刊论文

  • 发表日期：

    2025年1月21日

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  • Yujuan Xiang,
  • Hongpeng Yu,
  • Kegang Wu,
  • Ziting Quan,
  • Dong He,
  • Cansheng Ou,
  • Xianghua Chai,
  • Yinglin Liang,
  • Xuejuan Duan,
  • Xiangyu Zhang,
  • Qin Zha,
  • Wei Xie

摘要

A smartphone-based non-invasive method was developed for salivary uric acid detection using Gleditsia Sinensis carbon dots (GS-CDs). The GS-CDs synthesized by the one-pot hydrothermal method emitted blue fluorescence at a maximum excitation wavelength of 350 nm and had good fluorescence stability in the presence of different ions, while showing selectivity to uric acid solution. The ability of uric acid (UA) to quench the fluorescent substances present in the GS-CDs, was confirmed through HPLC-FLD and LC–MS, FTIR and XPS. The results showed that UA reacted with GS-CDs, with a decrease in hydroxyl groups and the formation of carboxyl groups. The fluorescence quenching suggested a possible dynamic quenching mechanism. In addition, a smartphone-based non-invasive detection method was developed for the detection of salivary UA levels, which reflects blood UA levels. This study provides a new perspective on the utilization of GS shells and advances the development of non-invasive testing for UA.

Graphical Abstract