<p>Characterizing the poromechanical and hydraulic responses of low-permeability rocks is crucial for ensuring the integrity and success of geoenergy systems. However, experimentally measuring these properties in tight rocks is a lengthy process due to the slow pore pressure diffusion and the long time required to reach full saturation and equilibrium. Particularly, determining the Biot coefficient can be challenging, as it often requires separate measurements of different poroelastic properties, which takes more time. We introduce a novel method to efficiently determine the Biot coefficient and permeability simultaneously, with the aid of numerical simulation. This method utilizes the partially drained response during a rapid Bouteca–Gueguen experiment, which is affected by rock compressibility, Biot coefficient, and permeability. We fine-tune these parameters in the simulation to match the experimental result. We tested this method on two different low-permeability porous materials: Aztec siltstone and consolidated kaolinite. Results demonstrated that this method can efficiently determine three different parameters simultaneously from a single experiment—drained bulk modulus (<i>K</i>), Biot coefficient (<i>α</i>), and permeability (<i>k</i>)—using non-equilibrium response analysis. We conducted an error analysis to estimate the range of the property values, considering potential experimental errors and anisotropy. This novel technique can increase the efficiency of measuring poromechanical material properties in low-permeability rocks for diverse geoenergy applications.</p>