Purpose <p>This study investigated the prognostic impact of the absolute lymphocyte count-to-fibrinogen ratio (LFR) in patients undergoing curative resection for colorectal cancer.</p> Methods <p>Data from patients who underwent curative resection for colorectal cancer were retrospectively analyzed. The patients were divided into high and low LFR groups, and the relationships between LFR, disease-free survival (DFS), and overall survival (OS) were evaluated. Survival curves were generated using the Kaplan–Meier method, and multivariate analyses using Cox proportional hazards models were performed to identify the independent prognostic factors.</p> Results <p>Preoperative LFR was significantly associated with DFS and OS (both <i>P</i> &lt; 0.01) after curative resection of colorectal cancer. A multivariate analysis revealed that the depth of invasion (T3 or T4) (<i>P</i> &lt; 0.01, <i>P</i> = 0.02), lymph node metastasis (both <i>P</i> &lt; 0.01), and LFR (both <i>P</i> &lt; 0.01) were independent predictors of DFS and OS. In addition, patients in the low LFR group showed significantly higher inflammatory status and poorer nutritional profiles, including higher neutrophil-to-lymphocyte and C-reactive protein-to-albumin ratios (both <i>P</i> &lt; 0.01) and lower prognostic nutritional index (<i>P</i> &lt; 0.01) than those in the high LFR group.</p> Conclusions <p>Preoperative LFR can be a prognostic factor for a poor postoperative prognosis in patients with colorectal cancer, suggesting an important role for LFR in assessing nutritional and inflammatory status.</p>