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Purpose <p>Postoperative complications may affect the long-term outcomes after colorectal cancer (CRC) surgery. This multicenter study compared prognostic factors for overall survival (OS) in younger (≤ 74 years) and older (≥ 75 years) patients after curative resection for CRC, focusing on the 1-year and post-1-year outcomes.</p> Methods <p>We analyzed data from 1582 patients who underwent curative surgery for CRC at six hospitals between April 2016 and December 2019. Kaplan–Meier and Cox models were used to identify the risk factors for complications and survival.</p> Results <p>Older patients had a significantly worse overall survival (OS) and survival beyond the 1-year landmark. Postoperative complications were associated with increased 1-year mortality in both age groups. In younger patients, survival beyond 1 year was associated with a positive N status and a low BMI. In contrast, in older patients, postoperative complications remained associated with survival beyond the 1-year landmark, along with a male sex, positive N status, and poor ASA-PS.</p> Conclusions <p>The prolonged impact of complications on survival in older patients with CRC underscores the need for age-specific surgical strategies and proactive complication management.</p>

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Risk factors for one-year mortality and the subsequent prognosis in older patients undergoing curative surgery for colorectal cancer: a retrospective multicenter study

  • 期刊论文

  • 发表日期：

    2026年7月1日

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  • Shintaro Hashimoto,
  • Tetsuro Tominaga,
  • Keisuke Noda,
  • Toshio Shiraishi,
  • Mariko Yamashita,
  • Hiroki Katayama,
  • Shoko Tei,
  • Taiji Hida,
  • Hiroshi Maruta,
  • Yuma Takamura,
  • Rika Ono,
  • Makoto Hisanaga,
  • Mitsutoshi Ishii,
  • Masaaki Moriyama,
  • Hidetoshi Fukuoka,
  • Kazuo To,
  • Kaido Oishi,
  • Hiroaki Takeshita,
  • Terumitsu Sawai,
  • Takashi Nonaka,
  • Keitaro Matsumoto

摘要

Purpose

Postoperative complications may affect the long-term outcomes after colorectal cancer (CRC) surgery. This multicenter study compared prognostic factors for overall survival (OS) in younger (≤ 74 years) and older (≥ 75 years) patients after curative resection for CRC, focusing on the 1-year and post-1-year outcomes.

Methods

We analyzed data from 1582 patients who underwent curative surgery for CRC at six hospitals between April 2016 and December 2019. Kaplan–Meier and Cox models were used to identify the risk factors for complications and survival.

Results

Older patients had a significantly worse overall survival (OS) and survival beyond the 1-year landmark. Postoperative complications were associated with increased 1-year mortality in both age groups. In younger patients, survival beyond 1 year was associated with a positive N status and a low BMI. In contrast, in older patients, postoperative complications remained associated with survival beyond the 1-year landmark, along with a male sex, positive N status, and poor ASA-PS.

Conclusions

The prolonged impact of complications on survival in older patients with CRC underscores the need for age-specific surgical strategies and proactive complication management.