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Purpose <p>The impact of the number of lymph nodes removed on prognosis in patients with pathological node-positive disease is still unclear.</p> Methods <p>We retrospectively reviewed 672 colorectal cancer patients who underwent curative surgery and were diagnosed as node-positive pathologically. Patients were divided into two groups: those with a low number of retrieved lymph nodes (Group L, n = 127); and those with a high number (Group H, n = 545). Propensity score matching was applied to minimize the possibility of selection bias. Finally, 120 patients in each group were matched.</p> Results <p>Before matching, Group L showed lower frequencies of comorbidities (Group L vs Group R: 65.4% vs 77.1%, p = 0.008), involvement of the right-side colon (25.1% vs 35.0%, p = 0.036), and clinical T4 status (15.0% vs 25.1%, p = 0.014), and a higher frequency of clinical node-negative status (47.2% vs 29.0%, p &lt; 0.001). After matching, operation time was shorter (203&#xa0;min vs 239&#xa0;min, p = 0.005) and 5-year recurrence-free survival rate was poorer in Group L (57.8% vs 71.4%, p = 0.047).</p> Conclusions <p>In patients with Stage III colorectal cancer, lymph node dissection yielding ≤ 12 nodes may be associated with poor prognosis. Implementation of appropriate adjuvant therapy and consideration of optimal treatment content and duration are necessary.</p>

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Prognostic value of number of harvested lymph nodes in Stage III colorectal cancer patients

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Toshio Shiraishi,
  • Shintaro Hashimoto,
  • Tetsuro Tominaga,
  • Yuma Takamura,
  • Hiroki Katayama,
  • Mariko Yamashita,
  • Keisuke Noda,
  • Shoko Tei,
  • Rika Ono,
  • Mitsutoshi Ishii,
  • Kaido Oishi,
  • Masaaki Moriyama,
  • Takashi Onoda,
  • Takashi Nonaka,
  • Keitaro Matsumoto

摘要

Purpose

The impact of the number of lymph nodes removed on prognosis in patients with pathological node-positive disease is still unclear.

Methods

We retrospectively reviewed 672 colorectal cancer patients who underwent curative surgery and were diagnosed as node-positive pathologically. Patients were divided into two groups: those with a low number of retrieved lymph nodes (Group L, n = 127); and those with a high number (Group H, n = 545). Propensity score matching was applied to minimize the possibility of selection bias. Finally, 120 patients in each group were matched.

Results

Before matching, Group L showed lower frequencies of comorbidities (Group L vs Group R: 65.4% vs 77.1%, p = 0.008), involvement of the right-side colon (25.1% vs 35.0%, p = 0.036), and clinical T4 status (15.0% vs 25.1%, p = 0.014), and a higher frequency of clinical node-negative status (47.2% vs 29.0%, p < 0.001). After matching, operation time was shorter (203 min vs 239 min, p = 0.005) and 5-year recurrence-free survival rate was poorer in Group L (57.8% vs 71.4%, p = 0.047).

Conclusions

In patients with Stage III colorectal cancer, lymph node dissection yielding ≤ 12 nodes may be associated with poor prognosis. Implementation of appropriate adjuvant therapy and consideration of optimal treatment content and duration are necessary.