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Purpose <p>To evaluate the efficacy and safety of postoperative pleurodesis using OK-432, focusing on patients with idiopathic interstitial pneumonia (IIP).</p> Methods <p>This retrospective cohort study included patients who underwent OK-432 pleurodesis following pulmonary resection. We reviewed clinical characteristics, radiological evidence of IIP, operative findings, postoperative air leak volume, pleurodesis details, morbidity, and mortality; then we compared the outcomes of patients with vs. those without IIP, and analyzed the predictors of ≥Grade II complications.</p> Results <p>Pleurodesis was performed in 361 patients, including 67 (19%) with IIP. No significant differences were observed in the incidence of fever or in postpleurodesis parameters. The initial success rate was 58.2% for IIP patients and 70.4% for non-IIP patients. Recurrence developed in 7.5% of patients and surgical intervention was required in 4.1%. Risk factors for ≥Grade II complications included older age, IIP, pleurodesis within 3 postoperative days (PODs), and pre-pleurodesis WBC &gt; 7000/µL. Pneumonia after pleurodesis was more frequent in the IIP patients (11.9% vs. 2.4%, <i>p</i> &lt; 0.01).</p> Conclusions <p>There were no treatment-related deaths following OK-432 pleurodesis in IIP patients; however, IIP remained a significant risk factor for pleurodesis-related complications, particularly pneumonia. Early intervention and elevated WBC levels may increase the complication risk. Delaying pleurodesis until the WBC count normalizes is advisable to reduce adverse events.</p>

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Postoperative pleurodesis using OK-432 for pulmonary air leak in lung cancer patients with idiopathic interstitial pneumonia: A retrospective study

  • 期刊论文

  • 发表日期：

    2026年2月18日

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  • Mariko Fukui,
  • Takuya Ueda,
  • Kazuhiro Suzuki,
  • Takeshi Matsunaga,
  • Aritoshi Hattori,
  • Hisashi Tomita,
  • Kazuya Takamochi,
  • Kenji Suzuki

摘要

Purpose

To evaluate the efficacy and safety of postoperative pleurodesis using OK-432, focusing on patients with idiopathic interstitial pneumonia (IIP).

Methods

This retrospective cohort study included patients who underwent OK-432 pleurodesis following pulmonary resection. We reviewed clinical characteristics, radiological evidence of IIP, operative findings, postoperative air leak volume, pleurodesis details, morbidity, and mortality; then we compared the outcomes of patients with vs. those without IIP, and analyzed the predictors of ≥Grade II complications.

Results

Pleurodesis was performed in 361 patients, including 67 (19%) with IIP. No significant differences were observed in the incidence of fever or in postpleurodesis parameters. The initial success rate was 58.2% for IIP patients and 70.4% for non-IIP patients. Recurrence developed in 7.5% of patients and surgical intervention was required in 4.1%. Risk factors for ≥Grade II complications included older age, IIP, pleurodesis within 3 postoperative days (PODs), and pre-pleurodesis WBC > 7000/µL. Pneumonia after pleurodesis was more frequent in the IIP patients (11.9% vs. 2.4%, p < 0.01).

Conclusions

There were no treatment-related deaths following OK-432 pleurodesis in IIP patients; however, IIP remained a significant risk factor for pleurodesis-related complications, particularly pneumonia. Early intervention and elevated WBC levels may increase the complication risk. Delaying pleurodesis until the WBC count normalizes is advisable to reduce adverse events.