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Purpose <p>This study examined the relationship between preoperative prealbumin levels and long-term outcomes in patients with advanced gastric cancer after gastrectomy.</p> Methods <p>This study included patients who underwent radical gastrectomy for primary stage I–III gastric cancer with preoperative prealbumin levels measured from May 2006 to March 2017. The patients were categorized into 3 groups based on their preoperative prealbumin levels: high (≥ 22&#xa0;mg/dL), moderate (15–22&#xa0;mg/dL), and low (&lt; 15&#xa0;mg/dL).</p> Results <p>Of the 3,050 pStage I patients, 2488 (81.6%) were classified as high, 511 (16.8%) as moderate, and 51 (1.7%) as low. Of the 1682 patients with pStage II-III, 1161 (69.0%) were classified as high, 414 (24.6%) as moderate, and 107 (6.4%) as low. A comparison of the overall survival (OS) revealed that lower prealbumin levels were associated with a worse prognosis (P &lt; 0.001). A multivariate analysis indicated that prealbumin levels of 15–22&#xa0;mg/dL and &lt; 15&#xa0;mg/dL were independent poor prognostic factors for the OS, regardless of the pStage. When stratified by cause of death, prealbumin levels were associated with the other-cause survival but not the cancer-specific survival.</p> Conclusions <p>Preoperative prealbumin levels were correlated with the OS, especially the other-cause survival, in patients with gastric cancer after gastrectomy.</p> <p>(200 words). Data Access Statement: Research data supporting this publication are available from the NN repository at located at <a href="http://www.NNN.org/download/">www.NNN.org/download/</a>.</p>

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Low preoperative prealbumin increases non-gastric cancer mortality in patients with early or advanced gastric cancer after gastrectomy: a retrospective cohort study

  • 期刊论文

  • 发表日期：

    2025年8月23日

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  • Ryota Matsui,
  • Souya Nunobe,
  • Motonari Ri,
  • Rie Makuuchi,
  • Tomoyuki Irino,
  • Masaru Hayami,
  • Manabu Ohashi,
  • Takeshi Sano

摘要

Purpose

This study examined the relationship between preoperative prealbumin levels and long-term outcomes in patients with advanced gastric cancer after gastrectomy.

Methods

This study included patients who underwent radical gastrectomy for primary stage I–III gastric cancer with preoperative prealbumin levels measured from May 2006 to March 2017. The patients were categorized into 3 groups based on their preoperative prealbumin levels: high (≥ 22 mg/dL), moderate (15–22 mg/dL), and low (< 15 mg/dL).

Results

Of the 3,050 pStage I patients, 2488 (81.6%) were classified as high, 511 (16.8%) as moderate, and 51 (1.7%) as low. Of the 1682 patients with pStage II-III, 1161 (69.0%) were classified as high, 414 (24.6%) as moderate, and 107 (6.4%) as low. A comparison of the overall survival (OS) revealed that lower prealbumin levels were associated with a worse prognosis (P < 0.001). A multivariate analysis indicated that prealbumin levels of 15–22 mg/dL and < 15 mg/dL were independent poor prognostic factors for the OS, regardless of the pStage. When stratified by cause of death, prealbumin levels were associated with the other-cause survival but not the cancer-specific survival.

Conclusions

Preoperative prealbumin levels were correlated with the OS, especially the other-cause survival, in patients with gastric cancer after gastrectomy.

(200 words). Data Access Statement: Research data supporting this publication are available from the NN repository at located at www.NNN.org/download/.