Scholarlink

Purpose <p>Myosteatosis, or excessive deposition of adipose tissue within skeletal muscle, has been widely used to explain an impaired muscle quality. This study aimed to investigate the association between preoperative myosteatosis and surgical outcomes in patients with non-small-cell lung cancer (NSCLC).</p> Methods <p>We retrospectively examined 492 patients who underwent anatomical lung resection for stages I–III NSCLC between January 2014 and December 2022. The patients were divided into low- and high-paraspinal muscle density (MD) groups based on the lowest quartile cutoff value of MD on contrast-enhanced computed tomography, with the low-MD group defined as having myosteatosis.</p> Results <p>The five-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly lower in the myosteatosis group than in the control group (59.1% vs. 86.8%, <i>P</i> &lt; 0.001; 52.0% vs. 72.6%, <i>P</i> &lt; 0.001, respectively). A multivariate analysis identified myosteatosis as an independent predictor of OS (hazard ratio [HR], 2.809; 95% confidence interval [CI], 1.781–4.430; <i>P</i> &lt; 0.001) and RFS (HR, 1.894; 95%CI, 1.340–2.678; <i>P</i> &lt; 0.001). There was a significant correlation between myosteatosis and prolonged air leak postoperatively (<i>P</i> = 0.039).</p> Conclusion <p>Perioperative nutritional and exercise interventions facilitate changes in body composition, which may improve the outcomes in patients with lung cancer undergoing anatomical resection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preoperative myosteatosis as a novel prognostic biomarker after anatomical lung resection for non-small cell lung cancer

  • 期刊论文

  • 发表日期：

    2025年4月26日

查看全文
  • Seijiro Sato,
  • Saeko Nakayama,
  • Hirohiko Shinohara

摘要

Purpose

Myosteatosis, or excessive deposition of adipose tissue within skeletal muscle, has been widely used to explain an impaired muscle quality. This study aimed to investigate the association between preoperative myosteatosis and surgical outcomes in patients with non-small-cell lung cancer (NSCLC).

Methods

We retrospectively examined 492 patients who underwent anatomical lung resection for stages I–III NSCLC between January 2014 and December 2022. The patients were divided into low- and high-paraspinal muscle density (MD) groups based on the lowest quartile cutoff value of MD on contrast-enhanced computed tomography, with the low-MD group defined as having myosteatosis.

Results

The five-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly lower in the myosteatosis group than in the control group (59.1% vs. 86.8%, P < 0.001; 52.0% vs. 72.6%, P < 0.001, respectively). A multivariate analysis identified myosteatosis as an independent predictor of OS (hazard ratio [HR], 2.809; 95% confidence interval [CI], 1.781–4.430; P < 0.001) and RFS (HR, 1.894; 95%CI, 1.340–2.678; P < 0.001). There was a significant correlation between myosteatosis and prolonged air leak postoperatively (P = 0.039).

Conclusion

Perioperative nutritional and exercise interventions facilitate changes in body composition, which may improve the outcomes in patients with lung cancer undergoing anatomical resection.