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Purpose <p>Inflammatory, nutritional, and immune biomarkers are associated with the prognosis of patients with various tumors. Recently, a comprehensive predictive biomarker, the hemoglobin, albumin, lymphocyte, and platelet (HALP) score, was introduced to predict clinical outcomes. We investigated the prognostic impact of preoperative HALP scores in patients who underwent hepatectomy for colorectal liver metastasis (CRLM).</p> Method <p>The subjects of this study were 209 patients who underwent hepatectomy for CRLM between February, 2005 and September, 2023. The HALP score was defined as (albumin [mg/dL] × hemoglobin [g/L] × lymphocyte [count/L]) / platelet [count/L]. The cutoff value was calculated according to the receiver operating characteristic curve based on 3-year survival.</p> Results <p>The cutoff value of the HALP score was 35, and a low HALP score was confirmed in 107 patients (51%). Multivariate analysis of disease-free survival identified lymph node metastasis (HR 1.53, <i>p</i> = 0.03), extrahepatic lesions (HR 2.48, <i>p</i> &lt; 0.01), and a low HALP score (HR 2.0, <i>p</i> &lt; 0.01) as independently poor prognostic factors. Multivariate analysis of overall survival identified extrahepatic lesions (HR 2.98, <i>p</i> &lt; 0.01), a high CEA (HR 1.78, <i>p</i> = 0.02), and a low HALP score (HR 1.92, <i>p</i> = 0.02) as independently poor prognostic factors.</p> Conclusions <p>The HALP score is a useful prognostic factor for patients undergoing hepatectomy for CRLM.</p>

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Prognostic significance of the hemoglobin, albumin, lymphocyte, platelet (HALP) score after hepatectomy for colorectal liver metastases

  • 期刊论文

  • 发表日期：

    2025年1月20日

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  • Kohei Okazaki,
  • Kenei Furukawa,
  • Koichiro Haruki,
  • Shinji Onda,
  • Yoshihiro Shirai,
  • Masashi Tsunematsu,
  • Tomohiko Taniai,
  • Michinori Matsumoto,
  • Ryoga Hamura,
  • Munetoshi Akaoka,
  • Tadashi Uwagawa,
  • Toru Ikegami

摘要

Purpose

Inflammatory, nutritional, and immune biomarkers are associated with the prognosis of patients with various tumors. Recently, a comprehensive predictive biomarker, the hemoglobin, albumin, lymphocyte, and platelet (HALP) score, was introduced to predict clinical outcomes. We investigated the prognostic impact of preoperative HALP scores in patients who underwent hepatectomy for colorectal liver metastasis (CRLM).

Method

The subjects of this study were 209 patients who underwent hepatectomy for CRLM between February, 2005 and September, 2023. The HALP score was defined as (albumin [mg/dL] × hemoglobin [g/L] × lymphocyte [count/L]) / platelet [count/L]. The cutoff value was calculated according to the receiver operating characteristic curve based on 3-year survival.

Results

The cutoff value of the HALP score was 35, and a low HALP score was confirmed in 107 patients (51%). Multivariate analysis of disease-free survival identified lymph node metastasis (HR 1.53, p = 0.03), extrahepatic lesions (HR 2.48, p < 0.01), and a low HALP score (HR 2.0, p < 0.01) as independently poor prognostic factors. Multivariate analysis of overall survival identified extrahepatic lesions (HR 2.98, p < 0.01), a high CEA (HR 1.78, p = 0.02), and a low HALP score (HR 1.92, p = 0.02) as independently poor prognostic factors.

Conclusions

The HALP score is a useful prognostic factor for patients undergoing hepatectomy for CRLM.