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Objetive <p>To analyze the Time in Tight Range (TITR) (70–140&#xa0;mg/dL) and assess their possible differences according to Time Below Range (TBR) in a cohort of type 1 diabetes mellitus people with Múltiple Daily Injections.</p> Patients and methods <p>355 adult users of Continuous Glucose Monitoring (CGM) with at least a HbA1c during the period October 1, 2023-October 1, 2024, and glucose data in the 90 days prior were included.</p> Results <p>Age 46.9 years (SD 13.6); 57.2% male; time of evolution 21.6 years (SD 12.6). Mean TITR was 38.4% (SD 14.6) and 20.3% had a TITR ≥ 50%. The correlation TITR-TIR was strong (β = 0.83; CI 95% 0.8–0.87; R [2] Adjusted 0.89; <i>p</i> &lt; 0.001) and varied according to TBR [TBR &lt; 4% group (β = 0.81; CI 95% 0.78 to 0.85; R [2] Adjusted 0.9; <i>p</i> &lt; 0.001) vs. TBR ≥ 4% (β = 0.9; CI 95% 0.86 to 0.94; R [2] Adjusted 0.93; <i>p</i> &lt; 0.001)]. The variables independently associated with TITR in patient with TBR &lt; 4% were HbA1c (β = -9.58; CI 95% -10.88 to -8.29; <i>p</i> &lt; 0.001) and Coefficient of Variation (CV) (β = -0.38; CI 95% -0.66 to -0.11; <i>p</i> = 0.007). However, in those with TBR ≥ 4% were male gender (β = 2.86; CI 95% 0.26 to 5.45; <i>p</i> = 0.031), HbA1c (β = -7.53; CI 95% -9.1 to -5.96; <i>p</i> &lt; 0.001) and CV (β = -0.69; CI 95% -1.01 to -0.37; <i>p</i> &lt; 0.001).</p> Conclusions <p>The correlation between TITR and TIR and the factors that were independently associated with TITR differ depending on the TBR.</p>

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Time in Tight Range (TITR) stratified by Time Below Range (TBR) in a cohort of patients with type 1 Diabetes Mellitus and Multiple Daily Injections. A real-life study

  • 期刊论文

  • 发表日期：

    2025年7月30日

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  • Sandra Herranz-Antolín,
  • Sofía Ramos-Garrido,
  • Verónica Esteban-Monge,
  • Clara Coton-Batres,
  • María Covadonga López-Virgos,
  • Silvia Lallena-Pérez,
  • Miguel Torralba

摘要

Objetive

To analyze the Time in Tight Range (TITR) (70–140 mg/dL) and assess their possible differences according to Time Below Range (TBR) in a cohort of type 1 diabetes mellitus people with Múltiple Daily Injections.

Patients and methods

355 adult users of Continuous Glucose Monitoring (CGM) with at least a HbA1c during the period October 1, 2023-October 1, 2024, and glucose data in the 90 days prior were included.

Results

Age 46.9 years (SD 13.6); 57.2% male; time of evolution 21.6 years (SD 12.6). Mean TITR was 38.4% (SD 14.6) and 20.3% had a TITR ≥ 50%. The correlation TITR-TIR was strong (β = 0.83; CI 95% 0.8–0.87; R [2] Adjusted 0.89; p < 0.001) and varied according to TBR [TBR < 4% group (β = 0.81; CI 95% 0.78 to 0.85; R [2] Adjusted 0.9; p < 0.001) vs. TBR ≥ 4% (β = 0.9; CI 95% 0.86 to 0.94; R [2] Adjusted 0.93; p < 0.001)]. The variables independently associated with TITR in patient with TBR < 4% were HbA1c (β = -9.58; CI 95% -10.88 to -8.29; p < 0.001) and Coefficient of Variation (CV) (β = -0.38; CI 95% -0.66 to -0.11; p = 0.007). However, in those with TBR ≥ 4% were male gender (β = 2.86; CI 95% 0.26 to 5.45; p = 0.031), HbA1c (β = -7.53; CI 95% -9.1 to -5.96; p < 0.001) and CV (β = -0.69; CI 95% -1.01 to -0.37; p < 0.001).

Conclusions

The correlation between TITR and TIR and the factors that were independently associated with TITR differ depending on the TBR.