Scholarlink

Aim <p>The potential effects of diabetes duration and glycemic control on ejection fraction (EF) in patients with heart failure (HF) remain unclear. We investigated the impact of diabetes duration and glycemic control on ejection fraction (EF), alongside other risk factors, in HF patients with type 2 diabetes mellitus (T2DM).</p> Materials and methods <p>This single-center retrospective study included 1265 patients who were admitted and discharged with a diagnosis of HF between January 2010 and January 2022, all of whom had a known diagnosis of T2DM prior to admission. The patients included in the study were divided into two groups: those with heart failure and reduced ejection fraction (HFrEF, EF ≤ 40%) and those with or mid-range or preserved ejection fraction (HFmrEF + HFpEF, EF &gt; 40%).</p> Results <p>Among the 1265 patients, 697 had HFrEF. The duration of diabetes was significantly longer (13 vs. 7 years, <i>p</i> &lt; 0.001) and HbA1c levels were higher (8.4 ± 1.6% vs. 7.7 ± 1.5%, <i>p</i> &lt; 0.001) in the HFrEF group. Multivariable analysis identified diabetes duration (OR 2.23, <i>p</i> &lt; 0.001), hypertension (OR:6.62, <i>p</i> &lt; 0.001), and the use of oral antidiabetic agents (OR 0.74, <i>p</i> = 0.042) as independent predictors of reduced EF. Prolonged diabetes duration was associated with a reduction in EF (AUC = 0.780, <i>p</i> &lt; 0.001). Conversely, although glycemic control was poorer in the HFrEF group, it was not an independent predictor of EF.</p> Conclusion <p>Prolonged diabetes duration significantly reduces EF, among HF patients with T2DM, independent of glycemic control and other risk factors. While poor glycemic control was more prevalent in HFrEF patients, it did not independently affect EF.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The impact of diabetes duration and glycemic control on ejection fraction in heart failure patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月7日

查看全文
  • Omer Dogan,
  • Hasan Ali Barman,
  • Ebru Serin,
  • Abdullah Omer Ebeoglu,
  • Adem Atici,
  • Ridvan Turkmen,
  • Ibrahim Temel,
  • Isilay Kok,
  • Omer Gok,
  • Ipek Aydin,
  • Pelinsu Elif Ozkan,
  • Ali Nayir,
  • Melike Kaya,
  • Cem Kurt,
  • Aylin Altun,
  • Kursad Oz,
  • Isil Uzunhasan,
  • Murat Kazım Ersanli,
  • Rasim Enar,
  • Sait Mesut Dogan

摘要

Aim

The potential effects of diabetes duration and glycemic control on ejection fraction (EF) in patients with heart failure (HF) remain unclear. We investigated the impact of diabetes duration and glycemic control on ejection fraction (EF), alongside other risk factors, in HF patients with type 2 diabetes mellitus (T2DM).

Materials and methods

This single-center retrospective study included 1265 patients who were admitted and discharged with a diagnosis of HF between January 2010 and January 2022, all of whom had a known diagnosis of T2DM prior to admission. The patients included in the study were divided into two groups: those with heart failure and reduced ejection fraction (HFrEF, EF ≤ 40%) and those with or mid-range or preserved ejection fraction (HFmrEF + HFpEF, EF > 40%).

Results

Among the 1265 patients, 697 had HFrEF. The duration of diabetes was significantly longer (13 vs. 7 years, p < 0.001) and HbA1c levels were higher (8.4 ± 1.6% vs. 7.7 ± 1.5%, p < 0.001) in the HFrEF group. Multivariable analysis identified diabetes duration (OR 2.23, p < 0.001), hypertension (OR:6.62, p < 0.001), and the use of oral antidiabetic agents (OR 0.74, p = 0.042) as independent predictors of reduced EF. Prolonged diabetes duration was associated with a reduction in EF (AUC = 0.780, p < 0.001). Conversely, although glycemic control was poorer in the HFrEF group, it was not an independent predictor of EF.

Conclusion

Prolonged diabetes duration significantly reduces EF, among HF patients with T2DM, independent of glycemic control and other risk factors. While poor glycemic control was more prevalent in HFrEF patients, it did not independently affect EF.