Scholarlink

Background <p>Total knee arthroplasty (TKA) in post-traumatic osteoarthritis (PTOA) presents challenges that are not encountered in primary osteoarthritis (OA) cases. Given the inconsistent evidence regarding the safety and efficacy of TKA after PTOA, this meta-analysis, seeks to provide a clear understanding of the additional risks that are associated in PTOA patients.</p> Methods <p>Following the PRISMA guidelines, PubMed, Cochrane, and Google Scholar (pages 1–20) were accessed and explored until January 2025. The extracted data consisted of complications (overall complications, mechanical complications, wound-related complications, prosthetic joint infection (PJI), instability, aseptic loosening, and medical complications), readmissions, manipulation under anesthesia (MUA), reoperations, and surgery-related parameters (operative time, estimated blood loss (EBL), and length of stay (LOS)).</p> Results <p>Seventeen retrospective articles were included in the meta-analysis, including 342,584 patients, with 7936 in the PTOA group and 334,648 in the OA group. PTOA patients were found to have higher rates of overall complications (Odds Ratio = 3.41; 95% CI 2.30–5.06, <i>p</i> &lt; .001) as well as specific complications, readmissions (Odds Ratio = 2.04; 95% CI 1.11–3.76, <i>p</i> = 0.02), MUA (Odds Ratio = 4.45; 95% CI 1.90–10.41, <i>p</i> &lt; .001), and reoperations (Odds Ratio = 2.30; 95% CI 1.72–3.07, <i>p</i> &lt; .001) than OA patients. Furthermore, PTOA patients had a longer operative time (Mean difference = 11.39 min; 95% CI 7.13–15.85, <i>p</i> &lt; .001) and more EBL (Mean difference = 114.47 ml; 95% CI 22.33–206.61, <i>p</i> &lt; .001) while having a shorter LOS (Mean difference =  − 0.24 days; 95% CI − 0.38– − 0.10, <i>p</i> &lt; .001).</p> Conclusion <p>Compared to patients with OA, patients with PTOA had a higher rate of overall complications and specific surgical complications, readmissions, MUA, reoperations, a lengthier operative time, and more EBL. However, they had a shorter LOS compared to OA patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Total knee arthroplasty in post-traumatic versus degenerative osteoarthritis: a meta-analysis of outcomes

  • 期刊论文

  • 发表日期：

    2025年7月26日

查看全文
  • Mohammad Daher,
  • Joseph E. Nassar,
  • Jonathan Liu,
  • Alan H. Daniels,
  • Mouhanad El-Othmani

摘要

Background

Total knee arthroplasty (TKA) in post-traumatic osteoarthritis (PTOA) presents challenges that are not encountered in primary osteoarthritis (OA) cases. Given the inconsistent evidence regarding the safety and efficacy of TKA after PTOA, this meta-analysis, seeks to provide a clear understanding of the additional risks that are associated in PTOA patients.

Methods

Following the PRISMA guidelines, PubMed, Cochrane, and Google Scholar (pages 1–20) were accessed and explored until January 2025. The extracted data consisted of complications (overall complications, mechanical complications, wound-related complications, prosthetic joint infection (PJI), instability, aseptic loosening, and medical complications), readmissions, manipulation under anesthesia (MUA), reoperations, and surgery-related parameters (operative time, estimated blood loss (EBL), and length of stay (LOS)).

Results

Seventeen retrospective articles were included in the meta-analysis, including 342,584 patients, with 7936 in the PTOA group and 334,648 in the OA group. PTOA patients were found to have higher rates of overall complications (Odds Ratio = 3.41; 95% CI 2.30–5.06, p < .001) as well as specific complications, readmissions (Odds Ratio = 2.04; 95% CI 1.11–3.76, p = 0.02), MUA (Odds Ratio = 4.45; 95% CI 1.90–10.41, p < .001), and reoperations (Odds Ratio = 2.30; 95% CI 1.72–3.07, p < .001) than OA patients. Furthermore, PTOA patients had a longer operative time (Mean difference = 11.39 min; 95% CI 7.13–15.85, p < .001) and more EBL (Mean difference = 114.47 ml; 95% CI 22.33–206.61, p < .001) while having a shorter LOS (Mean difference =  − 0.24 days; 95% CI − 0.38– − 0.10, p < .001).

Conclusion

Compared to patients with OA, patients with PTOA had a higher rate of overall complications and specific surgical complications, readmissions, MUA, reoperations, a lengthier operative time, and more EBL. However, they had a shorter LOS compared to OA patients.