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Objective <p>To explore the association between the serum calcium/phosphorus Ratio and the severity of spinal deformity in scoliosis patients and its clinical significance.</p> Methods <p>Based on retrospective cohort data from 141 non-surgically treated scoliosis patients at Department of Spine Surgery at Guangzhou First People’s Hospital between 2019 and 2025, the Ca/P Ratio and spinal deformity severity were analyzed. Multivariable logistic regression, restricted cubic spline (RCS) analysis, and subgroup analyses were conducted to assess the independent association between the Ca/P Ratio and deformity severity. Adjustments were performed for confounders to improve the validity of the findings.</p> Results <p>Patients in the highest Ca/P Ratio quartile (Q4) exhibited significantly milder spinal deformity (P&lt;0.001). Multivariable analysis demonstrated that each unit increase in the Ca/P Ratio was associated with a reduced risk of severe deformity (OR=0.25, 95% CI: 0.07-0.92, P=0.037). RCS analysis revealed a nonlinear association between the Ca/P Ratio and deformity severity (nonlinear P=0.0495). Subgroup analyses indicated that the protective effect was more pronounced in patients without hypertension/diabetes, males, those with lower BMI, or lower bone mineral density.</p> Conclusion <p>The serum Ca/P Ratio is an independent predictor of spinal deformity severity in scoliosis patients. Its imbalance may exacerbate spinal structural abnormalities by affecting bone metabolism.</p>

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Lower calcium/phosphorus ratio is associated with the severity of deformity in patients with scoliosis

  • 期刊论文

  • 发表日期：

    2026年4月20日

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  • Ruicong Li,
  • Min Wang,
  • Huiying Wang,
  • Shifeng Wen

摘要

Objective

To explore the association between the serum calcium/phosphorus Ratio and the severity of spinal deformity in scoliosis patients and its clinical significance.

Methods

Based on retrospective cohort data from 141 non-surgically treated scoliosis patients at Department of Spine Surgery at Guangzhou First People’s Hospital between 2019 and 2025, the Ca/P Ratio and spinal deformity severity were analyzed. Multivariable logistic regression, restricted cubic spline (RCS) analysis, and subgroup analyses were conducted to assess the independent association between the Ca/P Ratio and deformity severity. Adjustments were performed for confounders to improve the validity of the findings.

Results

Patients in the highest Ca/P Ratio quartile (Q4) exhibited significantly milder spinal deformity (P<0.001). Multivariable analysis demonstrated that each unit increase in the Ca/P Ratio was associated with a reduced risk of severe deformity (OR=0.25, 95% CI: 0.07-0.92, P=0.037). RCS analysis revealed a nonlinear association between the Ca/P Ratio and deformity severity (nonlinear P=0.0495). Subgroup analyses indicated that the protective effect was more pronounced in patients without hypertension/diabetes, males, those with lower BMI, or lower bone mineral density.

Conclusion

The serum Ca/P Ratio is an independent predictor of spinal deformity severity in scoliosis patients. Its imbalance may exacerbate spinal structural abnormalities by affecting bone metabolism.