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Purpose <p>Percutaneous vertebral augmentation (PVA) represents a mainstream minimally invasive surgical procedure for the treatment of osteoporotic vertebral compression fractures (OVCF). However, postoperative complications often arise from bone cement leakage (CL). This study aimed to conduct a comprehensive meta-analysis to identify risk factors for CL and established a risk appraisal model based on the findings.</p> Methods <p>We systematically reviewed seven major databases up to September 2024 to identify studies examining CL following PVA treatment in OVCF. Meta-analysis was performed using RevMan 5.4 software. The results were used to establish a risk appraisal model for CL.</p> Results <p>The meta-analysis identified several factors, including Cobb angle, Bone mineral density, Cement viscosity, Cement volume injected, Stage of bone cement injection, Cortical defect, Fracture severity, Intravertebral vacuum cleft, Basivertebral foramen sign and Number of vertebral fractures. The risk appraisal model constructed type Logit(<i>P</i>) = − 0.621 + 0.412<i>X</i> <sub>Cobb angle</sub> + 0.842<i>X</i> <sub>BMD</sub> + 0.842<i>X</i> <sub>Cement viscosity</sub> + 0.495<i>X</i> <sub>Cement volume injected</sub> + 0.432<i>X</i> <sub>Stage of bone cement injection</sub> + 0.775<i>X</i> <sub>Cortical defect</sub> + 0.438<i>X</i> <sub>Fracture severity</sub> + 0.358<i>X</i> <sub>IVC</sub> + 1.015<i>X</i> <sub>Basivertebral foramen sign</sub> + 0.742<i>X</i> <sub>Number of vertebral fractures</sub>. The receiver operating characteristic curve (ROC) curve showed an area under curve (<i>AUC</i>) of 0.831, and the Hosmer-Lemeshow test showed χ<sup>2</sup> = 5.933, which is a good predictor of CL.</p> Conclusion <p>The risk appraisal model was validated to have a moderately effective predictive value and can serve as a valuable tool for clinicians to assess leakage risk and improve patient management strategies during surgical interventions.</p>

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The establishment and validation of a risk appraisal model for cement leakage after percutaneous vertebral augmentation for osteoporotic vertebral compression fractures based on a meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月24日

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  • Aotian Lao,
  • Yu Wu,
  • Shuai Ouyang,
  • Zelin Zhou,
  • Jian Zou,
  • Zerui Liu,
  • Zhigang Zhang,
  • Guoliang Lu

摘要

Purpose

Percutaneous vertebral augmentation (PVA) represents a mainstream minimally invasive surgical procedure for the treatment of osteoporotic vertebral compression fractures (OVCF). However, postoperative complications often arise from bone cement leakage (CL). This study aimed to conduct a comprehensive meta-analysis to identify risk factors for CL and established a risk appraisal model based on the findings.

Methods

We systematically reviewed seven major databases up to September 2024 to identify studies examining CL following PVA treatment in OVCF. Meta-analysis was performed using RevMan 5.4 software. The results were used to establish a risk appraisal model for CL.

Results

The meta-analysis identified several factors, including Cobb angle, Bone mineral density, Cement viscosity, Cement volume injected, Stage of bone cement injection, Cortical defect, Fracture severity, Intravertebral vacuum cleft, Basivertebral foramen sign and Number of vertebral fractures. The risk appraisal model constructed type Logit(P) = − 0.621 + 0.412X Cobb angle + 0.842X BMD + 0.842X Cement viscosity + 0.495X Cement volume injected + 0.432X Stage of bone cement injection + 0.775X Cortical defect + 0.438X Fracture severity + 0.358X IVC + 1.015X Basivertebral foramen sign + 0.742X Number of vertebral fractures. The receiver operating characteristic curve (ROC) curve showed an area under curve (AUC) of 0.831, and the Hosmer-Lemeshow test showed χ2 = 5.933, which is a good predictor of CL.

Conclusion

The risk appraisal model was validated to have a moderately effective predictive value and can serve as a valuable tool for clinicians to assess leakage risk and improve patient management strategies during surgical interventions.