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Purpose <p>Stereotactic radiosurgery (SRS) is a commonly employed treatment for spinal metastases (SMs). Although the outcomes of hybrid therapy have been extensively documented, there is limited research on the definitive effectiveness of SRS, particularly CyberKnife (CK), which remains inadequately defined. This study seeks to assess the effectiveness of CK SRS for patients with SMs.</p> Methods <p>A retrospective, single-institution, study was conducted on patients with SMs who exclusively underwent CK treatment at a major university hospital between January 2021 and June 2024. Primary outcomes were local control (LC). Secondary outcomes included overall survival (OS), pain assessment (Numeric Rating Scale, NRS), functional status (Karnofsky Performance Status, KPS), and treatment-related toxicity.</p> Results <p>Sixty-one patients underwent CK treatment with a median follow-up of 10 months, without surgical intervention at the treated site. The 6-month and 12-month survival rates were 96. 4% and 94. 2%, respectively, while LC rates were 94. 6% and 92. 5%. Patient-reported outcomes demonstrated a significant improvement in pain relief, with a decrease in the NRS score from a pre-CK median of 3. 0 to a post-CK median of 2. 0 (<i>P</i> &lt; 0. 001). Additionally, there was no significant difference in KPS scores before and after treatment.</p> Conclusion <p>CK SRS provides effective local control, pain relief, and minimal toxicity in selected patients with spinal metastases without prior surgery and low-to-intermediate grade compression. Results are consistent with established SBRT literature. Multi-institutional validation studies are warranted.</p>

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Improved outcomes of cyberknife stereotactic radiosurgery for spinal metastases: a retrospective study of sixty-one cases in one single center

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Paziliya Aikelamu,
  • Zezhen Zhang,
  • Wei Zou,
  • Yun Guan,
  • Rong Xie,
  • Xin Wang

摘要

Purpose

Stereotactic radiosurgery (SRS) is a commonly employed treatment for spinal metastases (SMs). Although the outcomes of hybrid therapy have been extensively documented, there is limited research on the definitive effectiveness of SRS, particularly CyberKnife (CK), which remains inadequately defined. This study seeks to assess the effectiveness of CK SRS for patients with SMs.

Methods

A retrospective, single-institution, study was conducted on patients with SMs who exclusively underwent CK treatment at a major university hospital between January 2021 and June 2024. Primary outcomes were local control (LC). Secondary outcomes included overall survival (OS), pain assessment (Numeric Rating Scale, NRS), functional status (Karnofsky Performance Status, KPS), and treatment-related toxicity.

Results

Sixty-one patients underwent CK treatment with a median follow-up of 10 months, without surgical intervention at the treated site. The 6-month and 12-month survival rates were 96. 4% and 94. 2%, respectively, while LC rates were 94. 6% and 92. 5%. Patient-reported outcomes demonstrated a significant improvement in pain relief, with a decrease in the NRS score from a pre-CK median of 3. 0 to a post-CK median of 2. 0 (P < 0. 001). Additionally, there was no significant difference in KPS scores before and after treatment.

Conclusion

CK SRS provides effective local control, pain relief, and minimal toxicity in selected patients with spinal metastases without prior surgery and low-to-intermediate grade compression. Results are consistent with established SBRT literature. Multi-institutional validation studies are warranted.