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Objective <p>To compare the efficacy and safety of low-temperature plasma radiofrequency ablation combined with ozone injection versus the same dual therapy with additional collagenase for cervical disc herniation (CDH).</p> Methods <p>A prospective RCT enrolled 90 eligible CDH patients (30–80 years, single-level protrusion ≤ 1/3 spinal canal) at a tertiary hospital, randomizing them to a study group (<i>n</i> = 45, triple therapy) or control group (<i>n</i> = 45, low-temperature plasma radiofrequency ablation + ozone). Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA) scores were compared preoperatively and at 1 week, 1, 3, and 6 months postoperatively, with efficacy assessed via Modified MacNab Criteria.</p> Results <p>At 6 months, the study group showed significantly better VAS and JOA scores (<i>P</i> &lt; 0.05) and a 6-month excellent rate of 93.33% vs. 75.56% in controls (<i>P</i> &lt; 0.05). Both groups improved postoperatively, with no early differences. No severe adverse events occurred.</p> Conclusion <p>The addition of collagenase to ablation and ozone therapy significantly enhances long-term pain relief and functional recovery in CDH patients without increasing safety risks.</p>

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Efficacy and safety of low-temperature plasma radiofrequency ablation combined with ozone injection versus triple therapy including collagenase for cervical disc herniation: a randomized controlled trial

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • Ying Yang,
  • Zhenguo Gao,
  • Yulin Zhang,
  • Qifan Fang,
  • Jiang Liu,
  • Yongming Zhao,
  • Zeyu Wu

摘要

Objective

To compare the efficacy and safety of low-temperature plasma radiofrequency ablation combined with ozone injection versus the same dual therapy with additional collagenase for cervical disc herniation (CDH).

Methods

A prospective RCT enrolled 90 eligible CDH patients (30–80 years, single-level protrusion ≤ 1/3 spinal canal) at a tertiary hospital, randomizing them to a study group (n = 45, triple therapy) or control group (n = 45, low-temperature plasma radiofrequency ablation + ozone). Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA) scores were compared preoperatively and at 1 week, 1, 3, and 6 months postoperatively, with efficacy assessed via Modified MacNab Criteria.

Results

At 6 months, the study group showed significantly better VAS and JOA scores (P < 0.05) and a 6-month excellent rate of 93.33% vs. 75.56% in controls (P < 0.05). Both groups improved postoperatively, with no early differences. No severe adverse events occurred.

Conclusion

The addition of collagenase to ablation and ozone therapy significantly enhances long-term pain relief and functional recovery in CDH patients without increasing safety risks.