Purpose <p>Presentation of unreported results of balloon kyphoplasty used to treat an 11-year-old patient with osteogenesis imperfecta and a vertebral compression fracture with a follow-up of 10 years.</p> Methods <p>The aim of the present study was to report the outcome of the first case published of a pediatric patient with osteogenesis imperfecta treated with a balloon kyphoplasty. A male 11-year-old patient with a previously known diagnosis of osteogenesis imperfecta was treated in our center after a trauma caused by a fall on his back after a somersault on the beach. The patient presented a T12 burst fracture with biconcave morphology and volume loss in the central region of more than 60% of the vertebral body.</p> Results <p>Balloon kyphoplasty with polymethylmethacrylate was performed. The postoperative course was uneventful and after 10 years the patient remains asymptomatic without clinical or radiological complications.</p> Conclusion <p>We report the only application to date of balloon kyphoplasty in children with osteogenesis imperfecta. Because of the reproducibility of the technique, the security of the procedure, the effective analgesia and the absence of effect on the growth at 10 years, balloon kyphoplasty should be a therapeutic alternative to consider for the treatment of patients with osteogenesis imperfecta in pediatric age with vertebral fractures.</p>