Purpose <p>When spine fractures involve posterior wall damage, they pose a heightened risk of instability, consequently influencing treatment strategies. To enhance early diagnosis and refine treatment planning for these fractures, we implemented a radiomics analysis using deep learning techniques, based on both anteroposterior and lateral plain X-ray images.</p> Methods <p>Retrospective data were collected for 130 patients with spine fractures who underwent anteroposterior and lateral imaging at two centers (Center 1, training cohort; Center 2, validation cohort) between January 2010 and June 2024. The Vision Transformer (ViT) technique was employed to extract imaging features. The features selected through multiple methods were then used to construct a machine learning model using NaiveBayes and Support Vector Machine (SVM). The model’s performance was evaluated using the area under the curve (AUC) metric.</p> Results <p>12 features were selected to form the deep learning features. The SVM model using a combination of anteroposterior and lateral plain images showed good performance in both centers with a high AUC for predicting spine fractures with posterior wall injury (Center 1, AUC: 0.909, 95% CI: 0.763–1.000; Center 2, AUC: 0.837, 95% CI: 0.678–0.996). The SVM model based on the combined images outperformed both the individual position images and a spine surgeon with 3 years of clinical experience in classification performance.</p> Conclusions <p>Our study demonstrates that a radiomic model created by integrating anteroposterior and lateral plain X-ray images of the spine can more effectively predict spine fractures with posterior wall injury, aiding clinicians in making accurate diagnoses and treatment decisions.</p>