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<p>Obesity is a complicated metabolic disorder marked by the accumulation of excessive fat and associated disturbances in lipid metabolism, liver function and chronic low-grade inflammation. The present study investigated the potential of fulvic acid to counteract obesity induced by a high-fat diet (HFD) in Wistar rats. The rats were fed a high-fat diet for six weeks to induce obesity, after which fulvic acid (10, 20, and 40&#xa0;mg/kg) was given orally via oral gavage for nine weeks. Orlistat (5&#xa0;mg/kg) served as a reference standard. Rats fed with the high-fat diet showed a marked increase in body weight and body mass index, accompanied by elevated levels of total cholesterol, triglycerides, LDL, VLDL, liver enzymes, and inflammatory markers along with a reduction in HDL levels. Administration of fulvic acid led to notable and dose-dependent improvements in these parameters. The highest dose (40&#xa0;mg/kg) demonstrated the greatest efficacy, including a reduction in body weight. It also contributed to normalization of lipid profile, restoration of liver enzymes levels, and improvements in inflammatory markers. Furthermore, higher doses significantly enhanced the excretion of fecal fat, suggesting decreased absorption of intestinal fat. This study provides in vivo evidence supporting the anti-obesity potential of fulvic acid and emphasizes its role in improving metabolic disturbances associated with obesity. These findings suggest that fulvic acid could serve as a promising natural agent for the management of obesity.</p> Graphical abstract <p></p>

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Fulvic acid improves lipid metabolism and fecal fat excretion in obese rats fed with high-fat diet

  • 期刊论文

  • 发表日期：

    2026年8月1日

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  • Vinit Kumar Sharma,
  • Deepika Rani,
  • Ranjit Singh,
  • Mona Piplani,
  • Pankaj Bhateja

摘要

Obesity is a complicated metabolic disorder marked by the accumulation of excessive fat and associated disturbances in lipid metabolism, liver function and chronic low-grade inflammation. The present study investigated the potential of fulvic acid to counteract obesity induced by a high-fat diet (HFD) in Wistar rats. The rats were fed a high-fat diet for six weeks to induce obesity, after which fulvic acid (10, 20, and 40 mg/kg) was given orally via oral gavage for nine weeks. Orlistat (5 mg/kg) served as a reference standard. Rats fed with the high-fat diet showed a marked increase in body weight and body mass index, accompanied by elevated levels of total cholesterol, triglycerides, LDL, VLDL, liver enzymes, and inflammatory markers along with a reduction in HDL levels. Administration of fulvic acid led to notable and dose-dependent improvements in these parameters. The highest dose (40 mg/kg) demonstrated the greatest efficacy, including a reduction in body weight. It also contributed to normalization of lipid profile, restoration of liver enzymes levels, and improvements in inflammatory markers. Furthermore, higher doses significantly enhanced the excretion of fecal fat, suggesting decreased absorption of intestinal fat. This study provides in vivo evidence supporting the anti-obesity potential of fulvic acid and emphasizes its role in improving metabolic disturbances associated with obesity. These findings suggest that fulvic acid could serve as a promising natural agent for the management of obesity.

Graphical abstract