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<p>Gentamicin is an aminoglycoside antibiotic widely used against gram-negative bacterial infections, but its administration is often accompanied by nephrotoxicity. <i>Rhodiola rosea</i> L., a well-known adaptogen, exhibits antioxidant and anti-inflammatory properties and has shown protective effects in conditions such as cardiovascular and neurodegenerative diseases, diabetes, sepsis, and cancer. It is also traditionally used to enhance physical endurance, support the nervous system, and improve cognitive function. This study aimed to evaluate the nephroprotective effect of <i>R. rosea</i> extract during gentamicin-induced kidney injury in Wistar rats, while also assessing systemic inflammation. Twenty-four animals were divided into four groups: control, G (175&#xa0;mg/kg gentamicin, intraperitoneally), R (175&#xa0;mg/kg <i>R. rosea</i> extract, orally), and G + R (co-administration of both treatments). The experiment lasted 12&#xa0;days, after which hematological and biochemical parameters were analyzed. Significant differences were observed in most measured variables, including RBC count, hemoglobin, hematocrit, MCV, MCH, MCHC, WBC count, CRP, creatinine, urea, cholesterol, HDL, glucose, total bilirubin, uric acid, AST, ALT, and LDH, while total protein levels remained unchanged. Changes observed after gentamicin administration suggested renal impairment and alterations associated with inflammatory and oxidative stress responses, while simultaneous administration of <i>R. rosea</i> attenuated the changes of several parameters induced by gentamicin. These data highlight the potential of <i>R. rosea</i> to safeguard against biochemical and hematological disruptions induced by gentamicin.</p>

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Protective and anti-inflammatory potential of Rhodiola rosea against gentamicin-induced nephrotoxicity: evidence from a study in Wistar rats with emphasis on novel biomarkers

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Emina Zenkić,
  • Vernesa Karović,
  • Nejla Šehović,
  • Maja Mitrašinović-Brulić,
  • Damir Suljević

摘要

Gentamicin is an aminoglycoside antibiotic widely used against gram-negative bacterial infections, but its administration is often accompanied by nephrotoxicity. Rhodiola rosea L., a well-known adaptogen, exhibits antioxidant and anti-inflammatory properties and has shown protective effects in conditions such as cardiovascular and neurodegenerative diseases, diabetes, sepsis, and cancer. It is also traditionally used to enhance physical endurance, support the nervous system, and improve cognitive function. This study aimed to evaluate the nephroprotective effect of R. rosea extract during gentamicin-induced kidney injury in Wistar rats, while also assessing systemic inflammation. Twenty-four animals were divided into four groups: control, G (175 mg/kg gentamicin, intraperitoneally), R (175 mg/kg R. rosea extract, orally), and G + R (co-administration of both treatments). The experiment lasted 12 days, after which hematological and biochemical parameters were analyzed. Significant differences were observed in most measured variables, including RBC count, hemoglobin, hematocrit, MCV, MCH, MCHC, WBC count, CRP, creatinine, urea, cholesterol, HDL, glucose, total bilirubin, uric acid, AST, ALT, and LDH, while total protein levels remained unchanged. Changes observed after gentamicin administration suggested renal impairment and alterations associated with inflammatory and oxidative stress responses, while simultaneous administration of R. rosea attenuated the changes of several parameters induced by gentamicin. These data highlight the potential of R. rosea to safeguard against biochemical and hematological disruptions induced by gentamicin.