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<p>Oxidative stress has been implicated in the aging process and in the pathogenesis of chronic disorders, such as neurodegenerative diseases. Conversely, several edible mushrooms have been reported to exhibit antioxidant activities; however, their polysaccharides, especially when enriched with minerals, demonstrate even better antioxidant properties. Despite this, there is a paucity of data on the antioxidant properties of magnesium-enriched polysaccharides from mushrooms. This study evaluated the in vitro and in vivo antioxidant activities and the toxicological profile of a novel beta-glucan and mycelia obtained from magnesium-supplemented <i>Pleurotus ostreatus</i> (Mg-POP). The in vitro antioxidant activity of Mg-POP was determined by conventional assays. The in vivo antioxidant activity and toxicological profile of Mg-POP were investigated using an animal model. Forty adult Wistar rats were randomly allotted into 4 groups (<i>n</i> = 10 rats per group; 5 male Wistar rats and 5 female Wistar rats per group), and were orally gavaged 0, 100, 250, and 500&#xa0;mg/kg of Mg-POP for 28&#xa0;days. Mg-POP showed higher FRAP, ABTS, hydroxyl radical, and hydrogen peroxide radical-scavenging activities than ascorbic acid. Also, Mg-POP attenuated malondialdehyde and increased glutathione levels in the hepatic, renal, and cardiac tissues. In addition, Mg-POP did not alter body weight, organ weight indices, organ water content, and hematological variables. Furthermore, Mg-POP did not affect the injury markers and histoarchitecture of the hepatic, renal, and cardiac tissues. This study demonstrates that Mg-POP is non-toxic (at the tested doses) and exerts promising antioxidant activities.</p>

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Exploring the antioxidant activities and toxicological profile of a novel beta-glucan and mycelia obtained from magnesium-supplemented Pleurotus ostreatus

  • 期刊论文

  • 发表日期：

    2026年4月9日

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  • Roland Eghoghosoa Akhigbe,
  • Julius Kola Oloke

摘要

Oxidative stress has been implicated in the aging process and in the pathogenesis of chronic disorders, such as neurodegenerative diseases. Conversely, several edible mushrooms have been reported to exhibit antioxidant activities; however, their polysaccharides, especially when enriched with minerals, demonstrate even better antioxidant properties. Despite this, there is a paucity of data on the antioxidant properties of magnesium-enriched polysaccharides from mushrooms. This study evaluated the in vitro and in vivo antioxidant activities and the toxicological profile of a novel beta-glucan and mycelia obtained from magnesium-supplemented Pleurotus ostreatus (Mg-POP). The in vitro antioxidant activity of Mg-POP was determined by conventional assays. The in vivo antioxidant activity and toxicological profile of Mg-POP were investigated using an animal model. Forty adult Wistar rats were randomly allotted into 4 groups (n = 10 rats per group; 5 male Wistar rats and 5 female Wistar rats per group), and were orally gavaged 0, 100, 250, and 500 mg/kg of Mg-POP for 28 days. Mg-POP showed higher FRAP, ABTS, hydroxyl radical, and hydrogen peroxide radical-scavenging activities than ascorbic acid. Also, Mg-POP attenuated malondialdehyde and increased glutathione levels in the hepatic, renal, and cardiac tissues. In addition, Mg-POP did not alter body weight, organ weight indices, organ water content, and hematological variables. Furthermore, Mg-POP did not affect the injury markers and histoarchitecture of the hepatic, renal, and cardiac tissues. This study demonstrates that Mg-POP is non-toxic (at the tested doses) and exerts promising antioxidant activities.