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<p>In drug-induced liver injury, such as paracetamol toxicity, oxidative stress plays a crucial role. Researchers are increasingly interested in natural compounds with antioxidant properties as potential hepatoprotective agents to mitigate oxidative damage and prevent liver injury. This study evaluated the hepatoprotective effects of matcha tea using a rat model of paracetamol-induced liver injury. Wistar male rats were divided into five groups, each consisting of nine rats. The groups included a negative control, hepatotoxic control, positive control (silymarin), matcha tea powder treatment, and matcha tea extract treatment. Paracetamol was administered to induce liver injury, and subsequent analyses included liver function tests, oxidative stress markers, cytokines, and liver histopathology were conducted. Phytochemical analysis of matcha tea revealed high concentrations of caffeine, catechins, and epigallocatechin-3-gallate. The paracetamol-induced liver injury model was validated by significant increases in liver enzymes and proinflammatory cytokines. Pre-treatment with matcha tea powder significantly reduced AST and ALT levels, aligning them closely with healthy controls. Although reductions in ALP, GGT, and cytokines were observed, they were not statistically significant. The hepatoprotective effects of matcha are attributed to its rich phenolic and antioxidant content, suggesting its potential use in reversing paracetamol-induced liver toxicity. Matcha's strong antioxidant properties underscore its promise as a natural hepatoprotective agent.</p>

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Evaluation of the hepatoprotective effects of matcha tea on paracetamol-induced liver toxicity in rats

  • 期刊论文

  • 发表日期：

    2026年2月7日

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  • Tamam El-Elimat,
  • Zahraa M. Obeidat,
  • Nour A. Al-Sawalha,
  • Shreen D. Nusair,
  • Ahmed H. Al Sharie,
  • Feras El Hajji

摘要

In drug-induced liver injury, such as paracetamol toxicity, oxidative stress plays a crucial role. Researchers are increasingly interested in natural compounds with antioxidant properties as potential hepatoprotective agents to mitigate oxidative damage and prevent liver injury. This study evaluated the hepatoprotective effects of matcha tea using a rat model of paracetamol-induced liver injury. Wistar male rats were divided into five groups, each consisting of nine rats. The groups included a negative control, hepatotoxic control, positive control (silymarin), matcha tea powder treatment, and matcha tea extract treatment. Paracetamol was administered to induce liver injury, and subsequent analyses included liver function tests, oxidative stress markers, cytokines, and liver histopathology were conducted. Phytochemical analysis of matcha tea revealed high concentrations of caffeine, catechins, and epigallocatechin-3-gallate. The paracetamol-induced liver injury model was validated by significant increases in liver enzymes and proinflammatory cytokines. Pre-treatment with matcha tea powder significantly reduced AST and ALT levels, aligning them closely with healthy controls. Although reductions in ALP, GGT, and cytokines were observed, they were not statistically significant. The hepatoprotective effects of matcha are attributed to its rich phenolic and antioxidant content, suggesting its potential use in reversing paracetamol-induced liver toxicity. Matcha's strong antioxidant properties underscore its promise as a natural hepatoprotective agent.