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<p>Conessine, a naturally occurring steroidal glycoside, is present in the barks of <i>Holarrhena africana</i> and other related species, as well as in <i>Holarrhena antidysenterica</i>. Conessine has been documented to possess a variety of pharmacological properties. The objective of this investigation was to examine the hypolipidemic, antihyperglycemic, hepatoprotective, and antioxidant effects of conessine in hyperlipidemic rats induced by Triton X-100. Thirty adult male albino Wistar rats (150–200&#xa0;g) were randomly assigned to five groups: Group I (normal control), Group II (positive control, Triton X-100, 60&#xa0;mg/kg), Group III (standard drug, atorvastatin 10&#xa0;mg/kg), and Groups IV and V (conessine 20 and 50&#xa0;mg/kg, respectively). All treatments were administered in 0.5% CMC. We evaluated the lipid profile, liver function markers, hematological parameters, blood glucose, and antioxidant activity. Conessine resulted in a dose-dependent reduction (<i>p</i> &lt; 0.05) in serum triglycerides, total cholesterol, LDL-c, VLDL-c, and atherogenic indices, as well as an increase in HDL-c levels. In the DPPH radical scavenging assay, it also exhibited significant antioxidant activity, restored hematological values, and enhanced liver function markers. Additionally, conessine significantly decreased blood glucose levels, with the higher dose (50&#xa0;mg/kg) exhibiting effects that were comparable to those of atorvastatin. In hyperlipidemic rodents induced by Triton X-100, conessine demonstrated potent antioxidant, antihyperglycemic, and improvement in liver biochemical parameters, and hypolipidemic properties. These results suggest that conessine may be a promising natural bioactive compound with potential for further investigation for managing hyperlipidemia and its associated cardiovascular risks in a dose-dependent manner.</p> Graphical Abstract <p></p>

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Therapeutic potential of conessine: a multi-target approach against lipid, liver, oxidative, and glucose dysregulation in rat models

  • 期刊论文

  • 发表日期：

    2026年1月23日

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  • Anjali Singh,
  • Bhupendra Chauhan,
  • Amarjeet Singh

摘要

Conessine, a naturally occurring steroidal glycoside, is present in the barks of Holarrhena africana and other related species, as well as in Holarrhena antidysenterica. Conessine has been documented to possess a variety of pharmacological properties. The objective of this investigation was to examine the hypolipidemic, antihyperglycemic, hepatoprotective, and antioxidant effects of conessine in hyperlipidemic rats induced by Triton X-100. Thirty adult male albino Wistar rats (150–200 g) were randomly assigned to five groups: Group I (normal control), Group II (positive control, Triton X-100, 60 mg/kg), Group III (standard drug, atorvastatin 10 mg/kg), and Groups IV and V (conessine 20 and 50 mg/kg, respectively). All treatments were administered in 0.5% CMC. We evaluated the lipid profile, liver function markers, hematological parameters, blood glucose, and antioxidant activity. Conessine resulted in a dose-dependent reduction (p < 0.05) in serum triglycerides, total cholesterol, LDL-c, VLDL-c, and atherogenic indices, as well as an increase in HDL-c levels. In the DPPH radical scavenging assay, it also exhibited significant antioxidant activity, restored hematological values, and enhanced liver function markers. Additionally, conessine significantly decreased blood glucose levels, with the higher dose (50 mg/kg) exhibiting effects that were comparable to those of atorvastatin. In hyperlipidemic rodents induced by Triton X-100, conessine demonstrated potent antioxidant, antihyperglycemic, and improvement in liver biochemical parameters, and hypolipidemic properties. These results suggest that conessine may be a promising natural bioactive compound with potential for further investigation for managing hyperlipidemia and its associated cardiovascular risks in a dose-dependent manner.

Graphical Abstract