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<p>Polymicrobial infections involving both bacterial and fungal pathogens are challenging to manage in equine medicine due to biofilm formation and antimicrobial resistance. This case report aims to document the successful management of a complex injection site abscess in a 10-year-old Sudanese mare caused by a mixed bacterial and fungal infection. The mare presented with a 15-cm diameter abscess on the left lateral cervical region following repeated intramuscular multivitamin injections at the same site. Clinical examination revealed localised purulent discharge with a foul odour. Haematological analysis showed mild leukocytosis with absolute neutrophil leukocytosis (15.2 × 10<sup>3</sup>/μl), neutrophilia with a left shift, and lymphopaenia. Microbiological tests identified <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> using biochemical methods. <i>Candida albicans</i> was confirmed through culture characteristics, such as colour and morphology on CHROMagar, and molecular identification via ITS gene sequencing. Antimicrobial susceptibility testing revealed multidrug resistance in the bacterial isolates. They were only sensitive to fluoroquinolones, while <i>C. albicans</i> was sensitive only to clotrimazole. Management involved surgical debridement, daily wound irrigation with saline and povidone-iodine, and topical application of 1% clotrimazole cream twice daily. Systemic therapy included ciprofloxacin (7&#xa0;mg/kg IV every 24&#xa0;h) and vitamin C (7&#xa0;mg/kg IV every 24&#xa0;h), both administered for 7&#xa0;days. Complete wound healing was achieved in 22&#xa0;days without complications. This case underscores the importance of comprehensive diagnostic approaches, including fungal cultures in chronic equine wounds, and highlights the effectiveness of culture-guided antimicrobial therapy combined with aggressive wound management. Veterinarians should consider polymicrobial infections in persistent injection site abscesses and adopt proper injection techniques to prevent similar complications.</p>

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Management of a polymicrobial injection site abscess with molecularly confirmed Candida albicans in a Sudanese Mare: A case report

  • 期刊论文

  • 发表日期：

    2026年1月10日

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  • Olumide Odunayo Akinniyi,
  • Foluke Olajumoke Jemilehin,
  • Adelekan Oluseyi Okunlade,
  • Osereime Adah,
  • Veronica Olatimbo Ogunleye,
  • Akinlabi Oladele Ogunleye,
  • Olalekan Taiwo Jeremiah,
  • Temidayo Olutayo Omobowale

摘要

Polymicrobial infections involving both bacterial and fungal pathogens are challenging to manage in equine medicine due to biofilm formation and antimicrobial resistance. This case report aims to document the successful management of a complex injection site abscess in a 10-year-old Sudanese mare caused by a mixed bacterial and fungal infection. The mare presented with a 15-cm diameter abscess on the left lateral cervical region following repeated intramuscular multivitamin injections at the same site. Clinical examination revealed localised purulent discharge with a foul odour. Haematological analysis showed mild leukocytosis with absolute neutrophil leukocytosis (15.2 × 103/μl), neutrophilia with a left shift, and lymphopaenia. Microbiological tests identified Escherichia coli and Staphylococcus aureus using biochemical methods. Candida albicans was confirmed through culture characteristics, such as colour and morphology on CHROMagar, and molecular identification via ITS gene sequencing. Antimicrobial susceptibility testing revealed multidrug resistance in the bacterial isolates. They were only sensitive to fluoroquinolones, while C. albicans was sensitive only to clotrimazole. Management involved surgical debridement, daily wound irrigation with saline and povidone-iodine, and topical application of 1% clotrimazole cream twice daily. Systemic therapy included ciprofloxacin (7 mg/kg IV every 24 h) and vitamin C (7 mg/kg IV every 24 h), both administered for 7 days. Complete wound healing was achieved in 22 days without complications. This case underscores the importance of comprehensive diagnostic approaches, including fungal cultures in chronic equine wounds, and highlights the effectiveness of culture-guided antimicrobial therapy combined with aggressive wound management. Veterinarians should consider polymicrobial infections in persistent injection site abscesses and adopt proper injection techniques to prevent similar complications.