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<p>The present study investigated the phytochemical content of <i>Laurus nobilis</i> aqueous extract and its ameliorative effect on hydrogen peroxide-induced hepato-nephrotoxicity in Wistar rats. Total phenolic and flavonoid contents (TPC and TFC) and antioxidant activities were determined. For nephrohepatoprotective effect, the animal experiment comprised four groups: group 1 was the control group and received distilled water, group 2 was the normal group and received <i>L. nobilis</i> water extract (150 mg/kg bw), group 3 received 10% hydrogen peroxide solution, and group 4 simultaneously received hydrogen peroxide and aqueous extract of <i>L. nobilis</i> (150 mg/kg). Both treatments were administered daily via gavage. The hepatic enzymes, lipid profile, kidney parameters, and liver and kidney tissues were analyzed after 30 days of the experiment. The results revealed that <i>Laurus nobilis</i> aqueous extract contained considerable amounts of bioactive compounds (502.54 mg GAE/g, 122.08 mg QE/g, and 10.37 mg GAE/g, for TPC, TFC, and flavones, respectively). The aqueous extract revealed antioxidant activity by demonstrating inhibitory effects against DPPH and FRAP (0.063 and 0.16 µg/mL, respectively). Hydrogen peroxide-induced significant elevation of hepatic enzymes (alanine transaminase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH)), lipid profile, kidney markers, and histopathological injuries induced structural disorganization, congestion, hemorrhage, and Bowman’s space dilatation. Treatment with an aqueous extract of <i>L. nobilis</i> restored the balance of biochemical parameters. In conclusion, <i>Laurus nobilis</i> extract could protect against hydrogen peroxide-induced liver injuries, most likely thanks to its antioxidant properties.</p>

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Estimation of Laurus nobilis TPC and TFC contents and their ability against hydrogen peroxide-induced hepato-nephrotoxicity in Wistar rats

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Amal Taroq,
  • Driss Ousaaid,
  • Meryem Bakour,
  • Hassan Laaroussi,
  • Asmae El Ghouizi,
  • Yassine El Atki,
  • Nawal Hammas,
  • Fatima Zahra Talbi,
  • Badiaa Lyoussi

摘要

The present study investigated the phytochemical content of Laurus nobilis aqueous extract and its ameliorative effect on hydrogen peroxide-induced hepato-nephrotoxicity in Wistar rats. Total phenolic and flavonoid contents (TPC and TFC) and antioxidant activities were determined. For nephrohepatoprotective effect, the animal experiment comprised four groups: group 1 was the control group and received distilled water, group 2 was the normal group and received L. nobilis water extract (150 mg/kg bw), group 3 received 10% hydrogen peroxide solution, and group 4 simultaneously received hydrogen peroxide and aqueous extract of L. nobilis (150 mg/kg). Both treatments were administered daily via gavage. The hepatic enzymes, lipid profile, kidney parameters, and liver and kidney tissues were analyzed after 30 days of the experiment. The results revealed that Laurus nobilis aqueous extract contained considerable amounts of bioactive compounds (502.54 mg GAE/g, 122.08 mg QE/g, and 10.37 mg GAE/g, for TPC, TFC, and flavones, respectively). The aqueous extract revealed antioxidant activity by demonstrating inhibitory effects against DPPH and FRAP (0.063 and 0.16 µg/mL, respectively). Hydrogen peroxide-induced significant elevation of hepatic enzymes (alanine transaminase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH)), lipid profile, kidney markers, and histopathological injuries induced structural disorganization, congestion, hemorrhage, and Bowman’s space dilatation. Treatment with an aqueous extract of L. nobilis restored the balance of biochemical parameters. In conclusion, Laurus nobilis extract could protect against hydrogen peroxide-induced liver injuries, most likely thanks to its antioxidant properties.