<p>Acute phase proteins (APPs) fluctuate due to stress, infections, inflammation, trauma, or external stimuli in animals. In chickens, serum amyloid A (SAA) and ovotransferrin (OT) can serve as stress markers, enhancing animal welfare surveillance. This study aims to compare the predictive value of sialic acids (SA) and APPs in detecting inflammation-related conditions in chickens. APPs are nonspecific biomarkers that hold significant potential for monitoring the progression of infections or the effects of treatment in chickens. They can indicate the presence and severity of inflammation associated with infectious diseases, although they do not reveal the underlying cause. Compared to cytokines, APPs are more suitable for health monitoring due to their rapid clearance from the bloodstream. They can detect infections in chickens caused by bacteria, viruses, and protozoan parasites. APP concentrations in broiler chickens fluctuate during the early growth phases, highlighting the importance of monitoring multiple APPs in various conditions. Ovotransferrin, a moderately positive acute-phase protein in chickens, increases one to tenfold in response to stimuli and remains elevated during inflammation. SAA is useful for detecting acute lesions, including infectious bronchitis and ulcerative enteritis. Haptoglobin (Hp) levels are significantly elevated in infected chickens, making it a valuable diagnostic tool for predicting and identifying severe conditions. Fibrinogen, a mildly positive acute-phase protein, is useful for assessing inflammation and trauma in chickens. Lipid-bound sialic acid (LBSA) is the most variable parameter in diseased birds. It is highly sensitive to inflammatory conditions, such as infectious bronchitis, <i>Escherichia coli</i> lipopolysaccharide exposure, and Newcastle disease virus infection. Further research is needed to explore the behavior of these acute-phase proteins and sialic acids in chickens or to develop chicken-specific assays. This emerging field could provide valuable insights into the diagnostic potential of acute-phase proteins and sialic acids for chicken diseases. OT is a moderately positive acute-phase protein in chickens that increases markedly in response to infections, inflammation, and stress, making it a useful biomarker of disease and immune response. In conclusion, understanding the role and dynamics of APPs and sialic acids in chickens can significantly enhance the management of infectious diseases. Their application as diagnostic tools offers a promising avenue for improving poultry health and welfare.</p>