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<p>Northeast India is home to many herbal plants, so substantiating their medicinal properties with scientific proof is crucial. <i>Dillenia indica</i> possesses medicinal attributes, with its fruit harbouring numerous therapeutic properties. This study focuses on identifying the active phytocompounds of the fruit and assessing its antioxidant activities. The in vitro antioxidant potential of the aqueous fruit extract (AFE) and methanol fruit extract (MFE) of D. indica was evaluated using DPPH and FRAP methods. The in vivo antioxidant potential was evaluated by protein carbonylation, lipid peroxidation, and (γ-l-glutamyl-l-cysteinyl-glycine) GSH estimation assays in alloxan-induced diabetic mice. Gas chromatography-mass spectrometry (GC–MS) study of MFE was performed to identify active and primary compounds in D. indica fruit. A docking study was used to identify the compounds and check their ability to bind to critical proteins. The MFE demonstrated a greater inhibitory concentration compared to the AFE. This suggests that methanol is a more effective solvent for extraction, correlating with the higher levels of polyphenols and flavonoids found in the MFE, which contribute to its antioxidative activity. Identifying these phytocompounds can aid in scientifically documenting their medicinal value and potential applications in the pharmaceutical industry. Several of those compounds showed good binding affinity with pro-oxidant proteins. Given its potent free radical scavenging properties, it also serves as a valuable source of antioxidants. Conclusion: D.indica possess antioxidant effects against alloxan-induced oxidative stress. Thus, D.indica could be a potential cardioprotective agent for reducing cardiac damage.</p>

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Pharmacognostic evaluation of Dillenia indica L. fruit for its in-vitro and in-vivo antioxidant potential and investigation of bioactive phytocompounds using GC–MS and in-silico analysis

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • Plabita Sahariah,
  • Jutishna Bora,
  • Sumira Malik,
  • Surya Bhan,
  • Taranga Jyoti Baruah,
  • Sarvesh Rustagi,
  • Shailendra Thapliyal,
  • Nayan Talukdar,
  • Ravi Kumar Deshwal

摘要

Northeast India is home to many herbal plants, so substantiating their medicinal properties with scientific proof is crucial. Dillenia indica possesses medicinal attributes, with its fruit harbouring numerous therapeutic properties. This study focuses on identifying the active phytocompounds of the fruit and assessing its antioxidant activities. The in vitro antioxidant potential of the aqueous fruit extract (AFE) and methanol fruit extract (MFE) of D. indica was evaluated using DPPH and FRAP methods. The in vivo antioxidant potential was evaluated by protein carbonylation, lipid peroxidation, and (γ-l-glutamyl-l-cysteinyl-glycine) GSH estimation assays in alloxan-induced diabetic mice. Gas chromatography-mass spectrometry (GC–MS) study of MFE was performed to identify active and primary compounds in D. indica fruit. A docking study was used to identify the compounds and check their ability to bind to critical proteins. The MFE demonstrated a greater inhibitory concentration compared to the AFE. This suggests that methanol is a more effective solvent for extraction, correlating with the higher levels of polyphenols and flavonoids found in the MFE, which contribute to its antioxidative activity. Identifying these phytocompounds can aid in scientifically documenting their medicinal value and potential applications in the pharmaceutical industry. Several of those compounds showed good binding affinity with pro-oxidant proteins. Given its potent free radical scavenging properties, it also serves as a valuable source of antioxidants. Conclusion: D.indica possess antioxidant effects against alloxan-induced oxidative stress. Thus, D.indica could be a potential cardioprotective agent for reducing cardiac damage.