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<p>Atopic dermatitis (AD) is a lifelong inflammatory dermatosis associated with intense itching, scratching, and erythematous dry skin. <i>Conyza canadensis</i> is a medicinal herb enriched in polyphenols and flavonoids and has profound anti-inflammatory and antioxidant actions. To evaluate the anti-eczematous effect of topical flavonoid fraction in a mouse model of 1-chloro-2,4-dinitrobenzene (CDNB)-induced AD. Fifty Swiss albino-type mice were randomly divided into 5 groups of 10 each: control, induction, vehicle, tacrolimus, and flavonoid. The ethanolic extract of <i>Conyza canadensis</i> was evaluated by HPLC. Skin specimens were taken for histopathology, immunohistochemistry, and tissue homogenate analyses<b>.</b> Flavonoids from <i>Conyza canadensis</i> effectively lowered CDNB-exacerbated eczematous manifestations, as seen by diminished general dermatitis scores and scratching behaviors, along with a drop in overall leukocyte, neutrophil, and eosinophil percentages. Further, topical flavonoids profoundly hampered immunohistochemistry grades for IL-4 and IL-13, as well as amounts of IgE, MDA, IL-33, IL-17, IL-1β, and TNF-α in the skin. Isolated flavonoids also suppressed histologic scores, including cutaneous thickening/acanthosis and inflammatory cell penetration. Flavonoids of <i>Conyza canadensis</i> alleviates CDNB-evoked AD-like skin lesions thanks to its strengthening anti-inflammatory and anti-oxidative activities.</p>

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Flavonoids from Conyza Canadensis mitigates CDNB-induced mouse model of atopic dermatitis

  • 期刊论文

  • 发表日期：

    2025年9月3日

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  • Muataz Naeem Hussein,
  • Ahmed Rahmah Abu-Raghif,
  • Hayder Ridha-Salman,
  • Saja Majeed Shareef,
  • Rana Khairi Attarbashee,
  • Salim K. Hajwal,
  • Alhasan Haitham Habbas

摘要

Atopic dermatitis (AD) is a lifelong inflammatory dermatosis associated with intense itching, scratching, and erythematous dry skin. Conyza canadensis is a medicinal herb enriched in polyphenols and flavonoids and has profound anti-inflammatory and antioxidant actions. To evaluate the anti-eczematous effect of topical flavonoid fraction in a mouse model of 1-chloro-2,4-dinitrobenzene (CDNB)-induced AD. Fifty Swiss albino-type mice were randomly divided into 5 groups of 10 each: control, induction, vehicle, tacrolimus, and flavonoid. The ethanolic extract of Conyza canadensis was evaluated by HPLC. Skin specimens were taken for histopathology, immunohistochemistry, and tissue homogenate analyses. Flavonoids from Conyza canadensis effectively lowered CDNB-exacerbated eczematous manifestations, as seen by diminished general dermatitis scores and scratching behaviors, along with a drop in overall leukocyte, neutrophil, and eosinophil percentages. Further, topical flavonoids profoundly hampered immunohistochemistry grades for IL-4 and IL-13, as well as amounts of IgE, MDA, IL-33, IL-17, IL-1β, and TNF-α in the skin. Isolated flavonoids also suppressed histologic scores, including cutaneous thickening/acanthosis and inflammatory cell penetration. Flavonoids of Conyza canadensis alleviates CDNB-evoked AD-like skin lesions thanks to its strengthening anti-inflammatory and anti-oxidative activities.