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<p>Hypertension in the young is a global concern. This is due to early onset of target organ damage and increased cardiovascular morbidity. The interaction between many signalling pathways makes the pathophysiology of hypertension multifaceted, with multiple approaches to its management. The nuclear factor of activated T cells 1 (NFATc1) is one of these signaling molecules that has been implicated in hypertension. The present study investigated the association between NFATc1 and galectin-3 as well as metabolic profile in young hypertensives. This is a prospective case–control, multicenter study involving 110 hypertensive and 60 normotensive (control) participants aged 18–45 years. Participants were recruited consecutively after giving informed consent. Sociodemographic/clinical information and venous blood were obtained to estimate NFATc1, troponin-T, TGF-β1, NF-Kβ, galectin-3, and lipid profile. Atherogenic lipids were defined as TG/HDL and TC/HDL. Data were analysed using STATA 17 and Graphpad Prism version 10.2.3. The TG/HDL of 23.65 ± 16.66, TC/HDL of 19.78 (12.69–43.23), galectin-3 of 1.075 (0.11–2.08) ng/ml, NFATc1 of 1.085 (1.063–1.141) ng/mL, and NF-Kβ of 162.0 (122.9–188.1) pg/mL among HTN was significantly higher than TG/HDL of 0.95 ± 0.1561, TC/HDL of 4.243 (3.619–4.606), galectin-3 of 0.082 (0.07–0.11) ng/ml, NFATc1 of 0.09 (0.075–0.14) ng/mL, and NF-Kβ of 66.17 (56.45–72.56) pg/mL among NORM. There was a positive correlation between NFATc1 and galectin-3/LDL, and TG/HDL. Hypertension in young patients is associated with elevated levels of NFATc1 and increased markers of atherogenicity, inflammation, and fibrosis.</p>

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Association between NFATc1 and galectin-3/metabolic profile in young hypertensives

  • 期刊论文

  • 发表日期：

    2025年7月5日

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  • Busayo Onafowoke Oguntola,
  • Stephen Olawale Oguntola,
  • Richmond Opuye Odele,
  • Adams Olalekan Omoaghe,
  • Kehinde Samuel Olaniyi

摘要

Hypertension in the young is a global concern. This is due to early onset of target organ damage and increased cardiovascular morbidity. The interaction between many signalling pathways makes the pathophysiology of hypertension multifaceted, with multiple approaches to its management. The nuclear factor of activated T cells 1 (NFATc1) is one of these signaling molecules that has been implicated in hypertension. The present study investigated the association between NFATc1 and galectin-3 as well as metabolic profile in young hypertensives. This is a prospective case–control, multicenter study involving 110 hypertensive and 60 normotensive (control) participants aged 18–45 years. Participants were recruited consecutively after giving informed consent. Sociodemographic/clinical information and venous blood were obtained to estimate NFATc1, troponin-T, TGF-β1, NF-Kβ, galectin-3, and lipid profile. Atherogenic lipids were defined as TG/HDL and TC/HDL. Data were analysed using STATA 17 and Graphpad Prism version 10.2.3. The TG/HDL of 23.65 ± 16.66, TC/HDL of 19.78 (12.69–43.23), galectin-3 of 1.075 (0.11–2.08) ng/ml, NFATc1 of 1.085 (1.063–1.141) ng/mL, and NF-Kβ of 162.0 (122.9–188.1) pg/mL among HTN was significantly higher than TG/HDL of 0.95 ± 0.1561, TC/HDL of 4.243 (3.619–4.606), galectin-3 of 0.082 (0.07–0.11) ng/ml, NFATc1 of 0.09 (0.075–0.14) ng/mL, and NF-Kβ of 66.17 (56.45–72.56) pg/mL among NORM. There was a positive correlation between NFATc1 and galectin-3/LDL, and TG/HDL. Hypertension in young patients is associated with elevated levels of NFATc1 and increased markers of atherogenicity, inflammation, and fibrosis.