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<p>Body composition is considered a prognostic factor in breast cancer patients and the phosphoinositide 3-kinase (PI3K) tumor progression pathway is one of the most important signaling pathways in tumor development. The objective of the study is to evaluate the relationship between adiposity and muscle mass with positive expression of PI3K gamma and delta in women with breast cancer. A cross-sectional study was performed with 103 women. We collected sociodemographic, clinical, anthropometric, immunohistochemical, and body composition data. To analyze body composition, we used electrical bioimpedance, and, using the results of the resistance values, we calculated fat-free mass in kilos (FFM (kg)), as well as lean tissue mass in kilos (LSTM, (kg)), and then calculated fat mass in kilos (FM (kg)), percentage of fat-free mass (FFM%), percentage of fat mass (FM%), FFM index (FFMI (kg/m<sup>2</sup>)) and FM index (FMI (kg/m<sup>2</sup>)). Immunohistochemical information was obtained by mounting tissue microarray (TMAs) and then analyzing them for PI3K expression. Pearson’s <i>χ</i><sup>2</sup> test or Fisher’s exact test was applied for the association of qualitative variables. For differences in the means of anthropometric and body composition measurements by PI3K expression, we used the Student’s <i>t</i>-test for independent samples. Binary logistic regression models were structured to assess the impact of body compartments on the positive expression of PI3Ks. We adopted <i>p</i> &lt; 0.05. We found statistically significant results only about PI3K gamma, where patients with lower FFM (kg), LSTM (kg), and FFMI (kg/m<sup>2</sup>) showed positive immunoexpression of this protein. In addition, patients in the lowest tertile of muscle mass were more likely to have positive PI3K gamma immunoexpression. Breast cancer patients with lower muscle mass have higher tumor expression of PI3K gamma, possibly due to increased systemic inflammation and reduced anti-inflammatory cytokine release. Muscle mass does not influence PI3K delta expression. In addition, we found no association between obesity and positive expression of these markers.</p>

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Lower muscle mass is associated with higher PI3K gamma expression in breast cancer tumor tissue

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Vitória Maria Queiroz Machado,
  • Celia Choquenaira-Quispe,
  • Francisca Estefânia Mesquita Maciel de Lima,
  • Ítalo Aguiar Freire,
  • Deysi Viviana Tenazoa Wong,
  • Daniel Cordeiro Gurgel,
  • Roberto César Pereira Lima Júnior,
  • Débora Domingues Pinheiro,
  • Giselle de Andrade Barbosa,
  • Daniela Caetano Gonçalves,
  • Sara Maria Moreira Lima Verde

摘要

Body composition is considered a prognostic factor in breast cancer patients and the phosphoinositide 3-kinase (PI3K) tumor progression pathway is one of the most important signaling pathways in tumor development. The objective of the study is to evaluate the relationship between adiposity and muscle mass with positive expression of PI3K gamma and delta in women with breast cancer. A cross-sectional study was performed with 103 women. We collected sociodemographic, clinical, anthropometric, immunohistochemical, and body composition data. To analyze body composition, we used electrical bioimpedance, and, using the results of the resistance values, we calculated fat-free mass in kilos (FFM (kg)), as well as lean tissue mass in kilos (LSTM, (kg)), and then calculated fat mass in kilos (FM (kg)), percentage of fat-free mass (FFM%), percentage of fat mass (FM%), FFM index (FFMI (kg/m2)) and FM index (FMI (kg/m2)). Immunohistochemical information was obtained by mounting tissue microarray (TMAs) and then analyzing them for PI3K expression. Pearson’s χ2 test or Fisher’s exact test was applied for the association of qualitative variables. For differences in the means of anthropometric and body composition measurements by PI3K expression, we used the Student’s t-test for independent samples. Binary logistic regression models were structured to assess the impact of body compartments on the positive expression of PI3Ks. We adopted p < 0.05. We found statistically significant results only about PI3K gamma, where patients with lower FFM (kg), LSTM (kg), and FFMI (kg/m2) showed positive immunoexpression of this protein. In addition, patients in the lowest tertile of muscle mass were more likely to have positive PI3K gamma immunoexpression. Breast cancer patients with lower muscle mass have higher tumor expression of PI3K gamma, possibly due to increased systemic inflammation and reduced anti-inflammatory cytokine release. Muscle mass does not influence PI3K delta expression. In addition, we found no association between obesity and positive expression of these markers.