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<p><i>Premna latifolia</i> Roxb. an ethnomedicinal plant used from time immemorial according to Ayurveda has tremendous medicinal properties because of its phytochemical profiles. This work is therefore intended to assess the phytochemical composition and toxicological effect of <i>P. latifolia</i> Roxb. on rodents. The preliminary phytochemical investigation was conducted on the methanolic extract of the leaves they contain alkaloids, flavonoids, saponins, tannins, and phenolics. The GC–MS analysis has shown that squalene (13.57%), ergosta- 5,7,9 (11), 22-tetraen- 3-ol, (3. beta., 22E) -(0.15%), stigmasterol (3.73%), gamma-sitosterol (10.13%), lupeol (0.33), and beta-amyrin (2.27) were the most frequently found compounds out of the 66 compounds. To determine safety acute and sub-acute toxicity studies were carried out in rodents. In the acute toxicity study, no death or any loathsomeness transformation of behavior was recorded at a dose of 2000 mg/kg body weight. In a study involving groups of animals subjected to once-daily administration of the extract for 28 days, no change in haematological, biochemical, or histological profiles was observed at 125, 250, 500, and 1000 mg/kg. Taken together, these data support the hypothesis that the extract is safe at doses that produce therapeutic effects. This work showed that the phytochemical constituent of <i>Premna latifolia</i> Roxb. leaves extract is quite rich and safe for use based on the principles of traditional medicine and natural drug formulation. More research should be done to identify the various molecules in the plant and to determine their pharmacological actions.</p>

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Phytochemical Investigation and toxicity profiling of Premna latifolia Roxb. leaves extract in rodents

  • 期刊论文

  • 发表日期：

    2025年4月10日

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  • Rajesh Kumar,
  • Ashutosh Kumar,
  • Brijesh Kumar,
  • Ankush Goyal

摘要

Premna latifolia Roxb. an ethnomedicinal plant used from time immemorial according to Ayurveda has tremendous medicinal properties because of its phytochemical profiles. This work is therefore intended to assess the phytochemical composition and toxicological effect of P. latifolia Roxb. on rodents. The preliminary phytochemical investigation was conducted on the methanolic extract of the leaves they contain alkaloids, flavonoids, saponins, tannins, and phenolics. The GC–MS analysis has shown that squalene (13.57%), ergosta- 5,7,9 (11), 22-tetraen- 3-ol, (3. beta., 22E) -(0.15%), stigmasterol (3.73%), gamma-sitosterol (10.13%), lupeol (0.33), and beta-amyrin (2.27) were the most frequently found compounds out of the 66 compounds. To determine safety acute and sub-acute toxicity studies were carried out in rodents. In the acute toxicity study, no death or any loathsomeness transformation of behavior was recorded at a dose of 2000 mg/kg body weight. In a study involving groups of animals subjected to once-daily administration of the extract for 28 days, no change in haematological, biochemical, or histological profiles was observed at 125, 250, 500, and 1000 mg/kg. Taken together, these data support the hypothesis that the extract is safe at doses that produce therapeutic effects. This work showed that the phytochemical constituent of Premna latifolia Roxb. leaves extract is quite rich and safe for use based on the principles of traditional medicine and natural drug formulation. More research should be done to identify the various molecules in the plant and to determine their pharmacological actions.